Estimation of Blood Glucose as an Indirect Assessment For Attenuation Of Stress Response By Dexmedetomidine Versus Fentanyl Premedication During Laparoscopic Appendectomy: A Clinical Study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 3
Abstract
Background: Anaesthesia and surgery-induced neuroendocrine stress response can be modulated by appropriate premedication. The present study was done to assess the clinical efficacy of dexmedetomidine versus fentanyl premedication for attenuation of neuroendocrine stress response by analysing the perioperative variation of blood glucose level during Laparoscopic appendectomy under general anaesthesia. Methodology: 40 patients of ASA physical status I or II of either sex, aged between 20-60 yrs scheduled to undergo elective Laparoscopic appendectomy under general anaesthesia were randomly divided by envelope method into one of the 2 groups of 20 patients each (group D and group F). Patients allocated in group D (n = 20) were given IV infusion of dexmedetomidine 1μg/kg in 100 ml normal saline and Group F (n = 20) were given IV infusion of fentanyl 2 μg/kg in 100 ml normal saline over a 15 min period before the induction of general anaesthesia. Serial random blood sugar estimation was done perioperatively. Heart rate and mean arterial pressure were recorded at various time intervals. Results: Our study demonstrated that, there was increment in mean RBS value from the basal value, 30 mins after beginning of surgery, 28% and 31% in Group D and group F respectively, both of which were statistically significant. 10 mins following extubation there was 39% increase from the basal value in group F which was clinically and statistically significant (p <0.001) and 33% increase from the basal value in Group D which was also significant statistically (p <0.001). Conclusion: Both dexmedetomidine and fentanyl premedication attenuated the neuroendocrine stress response of laparoscopic appendectomy under general anaesthesia, as assessed by analysing the variation of blood glucose levels. The dexmedetomidine premedication was better when compared to fentanyl premedication.
Authors and Affiliations
Pramod D
Keywords
Related Articles
- EP ID EP501042
- DOI -
- Views 112
- Downloads 0
Impact of Calcium-Vitamin D Combination Tablets on the Dissolution Pattern of Four Different Brands of Rosuvastatin Calcium Tablets: An UV Analysis
This study was designed to find out the impact of calcium-vitamin-D combination tablets on the dissolution profile of rosuvastatin calcium tablets. For this purpose one of the highly prescribed brands of calcium-vitamin...
A Comparatively Study in vaginal hysterectomy and Laparoscopically assisted vaginal hysterectomy in women’s uterine infection
Background: Nowadays, there is a trend in favour of (Laparoscopically assisted vaginal hysterectomy) LAVH even for patients in whom (vaginal hysterectomy) VH is feasible. Hence, this study is undertaken to compare the ef...
Endodontic Management of Acute Apical Abscess: A Case Report.
Acute apical abscess is an inflammatory reaction to infection that may spread to extra-oral tissues. Knowledge of its clinical management is of utmost importance. This article describes the case of an 17-year-old girl wh...
To compare the fixed dose combination of drotaverine hydrochloride and mefenamic acid with intravenous sedation with injection pentazocine and diazepam in terms side effects at tertiary care hospital Rajasthan.
Background- Hysteroscopic examination with endometrial biopsy is currently the most informative investigation for patients with abnormal uterine bleeding and infertility. Methods- This study was conducted at the departme...
A Study on Evaluation of Salivary Gland Tumors Diagnosed Using Computed Tomography (CT)
Background: Tumours of salivary glands are heterogenous in nature and represent with complex clinical and pathological features. When malignant tumours are concerned, the mucoepidermoid carcinoma, the cystic adenoid carc...