Estimation of C - Reactive Protein, Magnesium and Uric Acid Levels in Pre-Eclampsia Patients in Comparison with Normal Pregnant Women
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 2
Abstract
Efforts to diagnose Preeclampsia have been hampered by inability to predict which women are likely to be affected. Because there is no standard diagnostic test yet available for preeclampsia, the present work used biomarkers to evaluate this condition. The aim of this study was to determine the level of C-reactive protein (CRP) in PE mothers along its relation with normal pregnant mothers. Another objective of this study is to find out the major markers to diagnose PE mothers among biochemical and hematological parameter. A case control study was conducted at Dept. of obstetrics and gynecology of our Hospital. 25 cases of PE mothers and age and gestational matched 25 cases of normal control pregnant mothers were included in this present study. CRP was estimated by NycoCard CRP reader. Serum Uric acid, SGPT, magnesium, calcium and Creatinine were estimated by fully automated analyzer. Neutrophils count, Total leukocyte count and Platelet counts were done in cell counter with peripheral direct smear and manual count correlation. Urine protein was detected by dipstick method. Results shows a significantly increased mean C-reactive protein in PE mothers (12.5 ± 3.8 mg/l) in comparison to normal control mother (1.2 ± 0.93 mg/L) with p value 0.03. Mean Serum magnesium observed lower in PE women (1.1± 0.4 mg/dl) than normal pregnant women (2.4± 0.2 mg/dl) with p value 0.02. We also found significance difference in SGPT, uric acid levels, whole blood count and neutrophil count between two groups. Among the all screened biochemical & hematological markers, Serum C-reactive protein, magnesium and uric acid levels along with blood cell count cumulatively can be measured and may be used as markers for early diagnosis of PE and can be reduced maternal as well as fetal morbidity and mortality.
Authors and Affiliations
K. Kameswaramma
Keywords
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