Estimation of Ciprofloxacin Hydrochloride in Bulk and Formulation by Derivative UV-Spectrophotometric Methods
Journal Title: International Journal of Advances in Scientific Research - Year 2015, Vol 1, Issue 3
Abstract
Simple, fast and reliable spectrophotometric methods were developed for determination of Ciprofloxacin Hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Distilled Water. The quantitative determination of the drug was carried out using the zero/0th, first, and second order method values measured at 264, 273 and 273 nm respectively. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Ciprofloxacin Hydrochloride using 2-10μg/ml (r²=0.9991, r²=0.9993, r²=0.9955) for zero, first and second order spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Ciprofloxacin Hydrochloride in pharmaceutical formulations.
Authors and Affiliations
Rekha Kharat, Santosh Balaso Jadhav, Dilshadbee Tamboli, Ashpak Tamboli
Keywords
Related Articles
- EP ID EP327849
- DOI 10.7439/ijasr.v1i3.1915
- Views 108
- Downloads 0
Model for Predicting and Analyzing the %Fe Removed as Deleterious Element from Al-Si alloys During Fe Removal Processing with Mn
Model equation for predicting and analysing %Fe removed from a eutectic Al-Si alloy during Fe removal processing with Mn under controlled conditions has been derived and validated. The model derived; % Fe removed = +1.30...
Prediction of selected anthropometric parameters on straid length performance for college level men short and long distance runners
In this study totally 30 athletes were selected randomly from Pondicherry University who are all participated intercollegiate athletic tournament in short and long distance events, in this 15 athletes from short distance...
A review on theoretical models of suicide
Suicide is a major public health issue which is highly complex and multifaceted. Subsequently, after the pioneering work of Durkheim and Freud, researchers and scholars have attempted to explain the biological, social, a...
Health effects caused by metal contaminated ground water
The main threats to human health are associated with the exposure to heavy metals like lead, cadmium, zinc, manganese, copper, nickel, chromium, mercury and arsenic. Even though adverse health effect due to heavy metals...
Effect of IBA concentration on the production of coratina olive plant
The effect of different concentrations of indole butyric acid (IBA) at 4g/L and 0.12/31.2 ml hardwood and semi hardwood cuttings of coratina olive was observed. Cuttings were taken in the month of February from coratina...