ESTIMATION OF ELETRIPTAN HYDROBROMIDE IN ORAL FILM DOSAGE FORM BY RP-HPLC
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 6
Abstract
A simple, precise, rapid and accurate RP-HPLC method was developed for the percentage drug release estimation of Eletriptan Hydrobromide in oral film dosage form. Eletriptan Hydrobromide is used to treat severe migraine headaches and it’s associated to nausea and sensitivity to light. Eletriptan Hydrobromide oral films were prepared by solvent casting method. It is available in market as conventional tablets (Relpax). An Xterra RP18 (150 × 4.6 with 5 microns particle size) and the mobile phase, consisting of KH2PO4 and triethylamine in water adjusting the pH-7.0 with o-phosphoric acid: acetonitrile in ratio of 98:2 v/v & acetonitrile: methanol HPLC Grade (80:20 v/v) was used as mobile phase in isocratic mode. The flow rate was 1.0 mL/min and the effluents were monitored at 225 nm. The retention time was 7.0 minutes and the detector response was linear in the concentration of 6.60-99.02µg/mL for Eletriptan Hydrobromide. The respective linear regression equation being Y = 11447 X + 5508 for Eletriptan Hydrobromide. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were not applicable for dissolution parameter. The method was validated by determining its accuracy, precision, linearity and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise, linear and accurate, which is useful for the routine estimation of percentage drug release of Eletriptan Hydrobromide in oral film dosage form.
Authors and Affiliations
Pavan Kumar Kothapuvari, Swati Rawat, Darna Bhikshapathi
Keywords
Related Articles
- EP ID EP625103
- DOI -
- Views 87
- Downloads 0
EFFECTS OF CURCUMIN ANALOGUE, 2, 6-BIS (2, 5-DIMETHOXYBENZYLIDENE) CYCLOHEXANONE (BDMC33) ON THE ACTIVITIES OF DRUG-METABOLIZING ENZYMES IN CULTURED CACO-2 CELL MODEL
Poor systemic delivery of curcumin outside the gut due to its rapid metabolism has severely limited its application to many chronic diseases. Previously, our research group synthesized curcumin analogues 2, 6-bis (2, 5-d...
THE NEWLY DEVELOPED HIGHLY SENSITIVE METHOD FOR THE DETERMINATION OF CAPECITABINE BY USING UV-SPECTROSCOPY
Capecitabine is a fluoropyrimidine carbamate, designed as 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) meant to be administered orally. Capecitabine is used as first line monotherapy for metastatic colorectal...
ENTACAPONE – BASED FLOATING MICROSPHERES BY IONOTROPIC GELATION TECHNIQUE-MORPHOLOGY AND RELEASE CHARACTERISTICS
The main objective of the present investigation was to develop gastro retentive floating microspheres for Entacapone. These are prepared by ionotropic gelation method with an aim of increasing the gastric residence time...
ROLE OF WITHANIA SOMNIFERA IN PREVENTION AND TREATMENT OF CANCER: AN OVERVIEW
Cancer is hyperproliferative disorder that involves transformation, dysregulation of apoptosis, proliferation, invasion, angiogenesis and metastasis. Millions of people die every year with different types of cancer such...
ACTIVITY OF AQUEOUS ETHANOL EXTRACT OF EUPHORBIA SCORDIFOLIA ON SHIGELLA DYSENTERIAE TYPE 1-INDUCED DIARRHEA IN RATS
Euphorbia scordifolia is traditionally used in Cameroon for the treatment of many diseases, including diarrhea. We investigated the effect of the aqueous ethanol extract of Euphorbia scordifolia (EWES) on intestinal prop...