ESTIMATION OF ELETRIPTAN HYDROBROMIDE IN ORAL FILM DOSAGE FORM BY RP-HPLC
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 6
Abstract
A simple, precise, rapid and accurate RP-HPLC method was developed for the percentage drug release estimation of Eletriptan Hydrobromide in oral film dosage form. Eletriptan Hydrobromide is used to treat severe migraine headaches and it’s associated to nausea and sensitivity to light. Eletriptan Hydrobromide oral films were prepared by solvent casting method. It is available in market as conventional tablets (Relpax). An Xterra RP18 (150 × 4.6 with 5 microns particle size) and the mobile phase, consisting of KH2PO4 and triethylamine in water adjusting the pH-7.0 with o-phosphoric acid: acetonitrile in ratio of 98:2 v/v & acetonitrile: methanol HPLC Grade (80:20 v/v) was used as mobile phase in isocratic mode. The flow rate was 1.0 mL/min and the effluents were monitored at 225 nm. The retention time was 7.0 minutes and the detector response was linear in the concentration of 6.60-99.02µg/mL for Eletriptan Hydrobromide. The respective linear regression equation being Y = 11447 X + 5508 for Eletriptan Hydrobromide. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were not applicable for dissolution parameter. The method was validated by determining its accuracy, precision, linearity and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise, linear and accurate, which is useful for the routine estimation of percentage drug release of Eletriptan Hydrobromide in oral film dosage form.
Authors and Affiliations
Pavan Kumar Kothapuvari, Swati Rawat, Darna Bhikshapathi
A NOVEL TECHNIQUE TO ENHANCE DISSOLUTION RATE OF CILNIDIPINE USING LIQUISOLID COMPACT & WET GRANULATION
The main objective of the work was to improve the dissolution rate of the drug, Cilnidipine (CLD) by using the liquisolid compact technique and wet granulation. Cilnidipine drug is poorly soluble in water and it’s highly...
Development and Correlation between in vitro Drug Release and in vitro Permeation of Thermally Triggered Mucoadhesive in situ Nasal Gel of Repaglinide PVP K30 Complex
The aim of the investigation was to develop and evaluate thermoreversible in situ nasal gel formulations of repaglinide (REP) and to establish correlation between its in vitro release and ex vivo permeation profiles. The...
EVALUATION OF TRACK ETCH MEMBRANE AS A SURROGATE FOR EX-VIVO DRUG PERMEATION STUDIES
The track etch membranes has attracted the attention of researchers, as a kind of novel material, for their various applications such as precise separation of biological cells, detection of biomolecules and controlled dr...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF ZINC OXIDE NANOPARTICLES SYNTHESIZED FROM CALOTROPIS PROCERA
The aim of the study was to compare the yield, nature and antimicrobial activity of nanoparticles synthesized using Calotropis procera leaf extract. ZnO NPs synthesized were characterized by FTIR and SEM. It was evident...
COMPARATIVE EVALUATION OF STAINLESS STEEL STENT (SIROLIMUS) AND COBALT CHROMIUM STENT (SIROLIMUS) IN PATIENT WITH CORONARY ARTERY DISEASE
Coronary Artery Disease (CAD) occurs when the arteries of the heart that normally provide blood and oxygen to the heart are narrowed or even completely blocked due to clot formation. The Stenting implantation composes 84...