ESTIMATION OF MALONDIALDEHYDE AND VITAMIN-E LEVELS IN NEONATAL HYPERBILIRUBINEMIA BEFORE AND AFTER PHOTOTHERAPY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 3
Abstract
Background: Hyperbilirubinemia is a common and benign problem in neonates worldwide. It is observed during the 1st week of life in approximately 60% of term neonates and 80% of preterm neonates. Phototherapy is most widely used as therapy for unconjugated hyperbilirubinemia. Phototherapy is related to oxidative stress and lipid peroxidation. The present study is undertaken to establish the relation between anti-oxidant status and the marker of lipid peroxidation in neonatal hyperbilirubinemia before and after phototherapy. Objectives: To estimate the levels of MDA (malondialdehyde) and vit-E levels in neonatal hyperbilirubinemia before and after phototherapy. Material and Methods: A total of 30 patients were eligible for the study who met the inclusion and exclusion criteria. Blood sample was collected from neonates of preterm/full term age 1 to 10 days with hyperbilirubinemia undergoing phototherapy. Total Bilirubin, Direct Bilirubin, MDA and vit-E levels were estimated in serum by thiobarbituric acid (TBA) method and Backer and Frank’s Method respectively. Results: The present study showed increase in Total bilirubin, Direct bilirubin, MDA and decrease in vit-E levels before phototherapy when compared to control group and same subjects after phototherapy showed decrease in Total bilirubin and Direct bilirubin, MDA and a further decrease in vit-E levels. Conclusion: From these results it is concluded though phototherapy had a beneficial effect in treatment of neonatal hyperbilirubinemia, supplementation of vit-E is necessary in addition to phototherapy.
Authors and Affiliations
Sidrah| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India, Corresponding author email:sidrah.biochem@gmail.com, Tandrapad Priyanka| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India, Asiya Naaz| Department of Biochemistry, SVS Medical College, Mahabubnagar, Telangana, India, Lakshmi Chaitanya G| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India, Sridevi D| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India
Keywords
Related Articles
- EP ID EP11441
- DOI 10.5958/2319-5886.2015.00107.1
- Views 233
- Downloads 12
Evaluation of Bacterial and fungal Contaminations in Barbershops in Kamyaran city, Iran-Summer 2015
Barbershops are considered as public places and can contribute to the transmission of many diseases. In this study, samples were obtained from a total of 18 barbershops in Kamyaran, Iran, to evaluate the type of bacteri...
A STUDY ON SOME PSYCHOLOGICAL HEALTH EFFECTS OF CELL-PHONE USAGE AMONGST COLLEGE GOING STUDENTS
Background: Cell phones have come to stay. Their use without any knowledge of their harmful effects like cancers and other health effects is not ‘quite’ safe. Studies on cancers due to electromagnetic radiations fr...
Review of Pharmacological Effects of Zataria multiflora Boiss. (Tyme of Shiraz)
Herbs were always important in supplying hygiene and society health regarding the treatment and diseases prevention and it still does. Traditional medicine has been used since a thousand years ago for the therapeutic ob...
Causes of Maternal Mortality: Autopsy Results
Background: Mortality of pregnant mother is one of the most important indices for evaluation of socioeconomic development of a society and can show effciency of health system of a country. Many causes of maternal mortal...
SALIVARY DUCT CARCINOMA OF PAROTID GLAND- AN INCIDENTAL FINDING
Salivary duct carcinoma, a recently added separate entity of salivary gland tumor is a rare tumour with its aggressive behaviour. Due to morphological similarities with ductal carcinoma of breast the name salivary duct...