ESTIMATION OF MALONDIALDEHYDE AND VITAMIN-E LEVELS IN NEONATAL HYPERBILIRUBINEMIA BEFORE AND AFTER PHOTOTHERAPY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 3
Abstract
Background: Hyperbilirubinemia is a common and benign problem in neonates worldwide. It is observed during the 1st week of life in approximately 60% of term neonates and 80% of preterm neonates. Phototherapy is most widely used as therapy for unconjugated hyperbilirubinemia. Phototherapy is related to oxidative stress and lipid peroxidation. The present study is undertaken to establish the relation between anti-oxidant status and the marker of lipid peroxidation in neonatal hyperbilirubinemia before and after phototherapy. Objectives: To estimate the levels of MDA (malondialdehyde) and vit-E levels in neonatal hyperbilirubinemia before and after phototherapy. Material and Methods: A total of 30 patients were eligible for the study who met the inclusion and exclusion criteria. Blood sample was collected from neonates of preterm/full term age 1 to 10 days with hyperbilirubinemia undergoing phototherapy. Total Bilirubin, Direct Bilirubin, MDA and vit-E levels were estimated in serum by thiobarbituric acid (TBA) method and Backer and Frank’s Method respectively. Results: The present study showed increase in Total bilirubin, Direct bilirubin, MDA and decrease in vit-E levels before phototherapy when compared to control group and same subjects after phototherapy showed decrease in Total bilirubin and Direct bilirubin, MDA and a further decrease in vit-E levels. Conclusion: From these results it is concluded though phototherapy had a beneficial effect in treatment of neonatal hyperbilirubinemia, supplementation of vit-E is necessary in addition to phototherapy.
Authors and Affiliations
Sidrah| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India, Corresponding author email:sidrah.biochem@gmail.com, Tandrapad Priyanka| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India, Asiya Naaz| Department of Biochemistry, SVS Medical College, Mahabubnagar, Telangana, India, Lakshmi Chaitanya G| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India, Sridevi D| Department of Biochemistry, Malla Reddy Institute of Medical Sciences, Hyderabad, India
Keywords
Related Articles
- EP ID EP11441
- DOI 10.5958/2319-5886.2015.00107.1
- Views 293
- Downloads 12
The Impact of Training on Nursing Process Implementation Skills of Surgical Ward Nurses
Nursing process is a systematic, patient-oriented and purposive approach which provides a framework for nursing performance. On the other hand, nursing process causes the nursing care to develop from traditional method...
EARLY OCULAR FINDINGS IN A PATIENT OF MAROTEAUX-LAMY SYNDROME
The Maroteaux-Lamy disease or mucopolysaccharidosis type VI is an inherited severe metabolic disorder which is very rare. It is caused by a deficiency of the enzyme Arylsulfatase B and characterized by a heterogeneous c...
Comparison of SOFA and APACHEII Scores in Predicting Weaning of Patients from Ventilator in the ICU Ward of Amin Hospital in Isfahan, Iran
Today, mechanical ventilation devices play an effective role in the improvement of patients. Prolonged mechanical ventilation and inappropriate weaning of patients from ventilators have undesirable consequences. To meas...
ROSAI-DORFMAN DISEASE WITH CERVICAL LYMPHADENOPATHY AND ORBITAL INVOLVEMENT: A CASE REPORT
Rosai-Dorfman disease (RDD), which is also called as sinus histiocytosis with massive lymphadenopathy (SHML), is a rare histiocytic disorder which occurs due to the over-production of non Langerhans sinus histiocytes....
MEASURING INAPPROPRIATE PRESCRIPTIONS IN GERIATRIC POPULATION: OVERVIEW OF VARIOUS SCREENING TOOLS
In this era of growing research, a plethora of effective therapeutic agents has been made available to treat chronic disorders that often accompany advancing age. However, medications often act as a “double edge swor...