Estimation of Matrix Metalloproteinases and their Tissue Inhibitors in Urine to Ascertain Noninvasive tools for Detecting Prostate Cancer
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Prostatic biopsy, though the gold standard investigation for prostate malignancy, often leads to unnecessary investigation with several complications. Our aim was to find out the cut off values, sensitivity, specificity and predictive values of urinary matrix metalloproteinases, their tissue inhibitors and free PSA to ascertain their suggestive role as noninvasive diagnostic tool for prostate cancer. Early morning urine samples of 40 clinically suggestive patients were collected and ELISA was done for MMP 7, 13, TIMP 1, 2 and free PSA followed by TRUS guided prostate biopsy. Values of MMP 7 and MMP 13 were found to have significant difference in levels between benign and malignant conditions. The cut off values in urine were obtained as free PSA>2.5mg/l, MMP 7>1ng/ml, MMP 13->75ng/ml, TIMP 1>4000pg/ml and TIMP 2>100pg/ml. MMP 13 and MMP 7 showed high sensitivity, specificity and predictive values while the tissue inhibitors and free PSA showed moderate to low sensitivity and specificity. MMP 13 having the most significant beta coefficient (0.263) was found to be the most significant parameter studied for diagnosing prostate carcinoma. Thus in the present study among different urinary parameters we found that MMP 13 is the most diagnostic tool for detecting prostate cancer followed by MMP 7 with doubtful roles of TIMP 1,TIMP 2 and free PSA.
Authors and Affiliations
Dr Jayanta Kumar Rout
Keywords
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