ESTIMATION OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE IN TABLET FORMULATIONS BY UV-VISIBLE SPECTROPHOTOMETRY
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2013, Vol 3, Issue 12
Abstract
In present research work attempt was made to estimate Metformin Hydrochloride and Glimepiride in combined Tablet formulations by UV-Visible spectrophotometric method. The dosage form contains 2 mg of Glimepiride and 500 mg of Metformin HCL and the ratio of both drugs in the dosage form is 1:250. Metformin HCL is freely soluble in water whereas Glimepiride is practically insoluble in water. So first both drugs are separated by solvent extraction method and then individually determined by UV absorbance method. Literature survey revealed that liquid chromatographic method and UV spectrophotometric method have been reported for estimation of Metformin HCL from combined dosage form. Also liquid chromatographic method and UV spectrophotometric method have been reported for estimation of Glimepiride23 from combined dosage form.
Authors and Affiliations
Dyade GK, Joshi HA, Patil RN
Keywords
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