Estimation of Pentraxin 3 and Porphyromonas Gingivalis Levels in Patients with Rheumatoid Arthritis and Periodontitis- An Observational Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: Periodontal diseases are inflammatory in nature involving interplay between the bacterial plaque and the microorganisms, with the response of the host playing a pivotal role in either attenuating or eliminating the disease. Rheumatoid Arthritis (RA) is also a chronic inflammatory disease which shares common risk factors with periodontitis. Porphyromonas Gingivalis and Pentraxin 3 (an acute inflammatory protein) have been observed to be associated with both the diseases. Aim: This study was done to determine if there was any association between Pophyromonas Gingivalis and Pentraxin 3 levels in patients with RA and Chronic Periodontitis in comparison with Healthy controls. Materials and Methods: This observational study was conducted on 90 subjects (42 Males and 48 Females) aged between 30-60 years. The subjects were selected from the out patient ward of a tertiary referral care hospital. The selected subjects were equally divided into three groups. Group I: Comprising of 30 patients with RA and chronic periodontitis who were in turn, subdivided into Group I- A (n=15) –Patients just diagnosed with RA and Group I- B (n=15) Patients under medications for more than three months. Group II: Patients with Chronic Periodontitis (n=30) and Group III: Healthy Controls (n=30) Intergroup comparison for continuous data was done by Oneway analysis of variance test followed by Bonferroni’s post-hoc test. Intragroup comparison for continuous data was done by paired t-test. Results: Intergroup comparison between Group I and Group II did not show any statistical difference pertaining to the clinical parameters except for the Gingival Index (GI) which was found to be higher in Group II (Mean= 2.07) when compared to Group I (Mean=1.59). Intragroup comparison between Group IA and Group IB was statistically significant for GI, Plaque Index (PI), and Clinical Attachment Levels (CAL). Intragroup comparison between Group I-A and Group I-B showed that both Porphyromonas gingivalis and Pentraxin 3 Levels were higher in Group I- A. Conclusion: In this study, it was observed that there was a positive association between Porphyromonas gingivalis and Pentraxin 3 levels in patients with rheumatoid arthritis and periodontitis.
Authors and Affiliations
Shankar Gittaboyina, Rekha Rani Koduganti, Srisaila Datta Aedula, Veerendra nath Reddy Panthula, Surya Prasanna Jammula, Rajashree Dasari, Himabindu Gireddy, Manasa Ambati
Keywords
Related Articles
- EP ID EP344344
- DOI 10.7860/JCDR/2017/24412.9792
- Views 74
- Downloads 0
Nonfunctional Cystic Hepatic Paraganglioma Mimicking Hydatid Cyst
An extra-adrenal pheochromocytoma is also known as a paraganglioma. We are reporting the case of a 68-year-old female patient with an extremely rare primary nonfunctioning hepatic paraganglioma without any clinical signs...
Content Validation of Total Knee Replacement Rehabilitation Protocol in Indian Population
Introduction: Total knee replacement (TKR) surgery has become the most successful surgery for patients with severe debilitating arthritis. The guidelines for rehabilitation progression should be tailored respecting the t...
Smartphone, the New Learning Aid amongst Medical Students
Introduction: The use of smartphone is increasing day by day for personal as well as professional purpose. They are becoming a more suitable tool for advancing education in developing countries. Mobile access to informat...
Idiopathic Tumoral Calcinosis – Rare Clinico Pathological Entity: A Report of Two Cases
Tumoral calcinosis is a rare disease reported mainly in blacks of tropical and subtropical African regions. It is characterized by tumour-like periarticular deposits of calcium that are found in the regions of the hip, s...
Echocardiography in Transfusion Dependent Beta Thalassaemia Major Egyptian Children: Correlation with Thyroid Function Status and Ferritin Level
ABSTRACT Introduction: Iron-mediated cardiomyopathy is leading cause of death in β-thalassaemia (βTM). Thyroid dysfunction maybe associated with cardiac dysfunctions. Early detection of cardiac-function impairment can he...