Estimation of Salivary Tumour Necrosis Factor-α Levels in Post-menopausal Women with Chronic Periodontitis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 5
Abstract
ABSTRACT Introduction: Periodontitis and increased levels of Tumor Necrosis Factor-alpha (TNF-α) are considered as key factors contributing to the bone loss observed in oestrogen deficient post-menopausal women. Aim: The present study aimed at assessing the levels of salivary TNF-α in pre- and post-menopausal women with chronic periodontitis and evaluating its potential as a biochemical marker of periodontal disease in post menopausal women. Materials and Methods: A total of 80 female subjects, within the age range of 35-55 years, were divided into 4 groups of 20 subjects each, pre- and post-menopausal women with chronic periodontitis and pre- and post-menopausal periodontally healthy controls. After assessment of clinical periodontal status, unstimulated whole saliva was collected and levels of TNF-α were examined using ELISA. One-way ANOVA, post-hoc Tukey’s test, Student’s unpaired t-test and Karl Pearson’s co-efficient of correlation were used. SPSS version 17.0 and MedCalc version 10.2 were used to perform the data analyses. Results: The mean of salivary TNF-α levels in pre- and post-menopausal women with chronic periodontitis were 4.25±1.20 pg/mL and 5.13±1.35 pg/mL, respectively, whereas that in pre- and post-menopausal healthy controls were 2.05±1.11 pg/mL and 2.40±1.08 pg/mL, respectively. The levels of salivary TNF-α were significantly higher in the periodontitis groups than the controls and correlated positively with the assessed clinical parameters (p<0.001). Also the levels were significantly higher in post-menopausal women with chronic periodontitis than the pre-menopausal women with chronic periodontitis (p<0.05). Conclusion: Salivary levels of TNF-α were increased in both menopause and chronic periodontitis. This increased secretion of TNF-α could be implicated as a contributing factor in the progression of periodontal disease in post-menopausal women, suggesting that salivary TNF-α can act as a potential biomarker and a valuable adjunct for screening of periodontal disease in post-menopausal women.
Authors and Affiliations
Pallavi Agrawal, Sheetal Sanikop, Suvarna Patil, Prateek Agrawal, Anil Agrawal
Keywords
Related Articles
- EP ID EP524442
- DOI 10.7860/JCDR/2018/32504.11488
- Views 78
- Downloads 0
Estimation of Stature from Hand Dimension among Indigenous Karbi Tribal Population of Assam, Northeast India
ABSTRACT Introduction: Estimation of stature is an important parameter in the personal identification from human remains such as hand, foot and limbs in forensic examination in the field of Forensic Anthropology. Aim: To...
Comparison of Intubating Conditions using Fentanyl plus Propofol Versus Fentanyl plus Midazolam during Fiberoptic Laryngoscopy
Introduction: Awake nasal or oral flexible fiberoptic intubation is the airway management technique of choice in known or anticipated difficult airway, unstable cervical fracture, limited mouth opening (as in temporomand...
Novel Methods and Regulation on Electronic Data Collection in Clinical Trials
Abstract The data collection is a pivotal part of clinical studies and impacts how the data is managed and analysed and the outcome of the clinical research besides contributing to the cost and duration of the clinical s...
A Five-year Retrospective Study on the Clinical Profile of Myasthenia Gravis with Ocular Involvement in a Tertiary Hospital
ABSTRACT Introduction: Myasthenia Gravis (MG) with ocular involvement has an elusive diagnosis. Ptosis and Diplopia are the most common and early presenting features of MG. Acetylcholine receptor (AChR) antibody titre, N...
Blastoid Variant of Mantle Cell Lymphoma with Leukemic Presentation - A Rare Case Report
Mantle Cell Lymphoma (MCL) is a type of Non-Hodgkin's lymphoma and has a wide spectrum of histopathological subtypes of which the blastoid or the blastic variant constitutes 10-15% of all cases. It is difficult to diagno...