Estimation of serum superoxide dismutase and glutathione peroxidase levels in tobacco chewers and smokers: A comparative study
Journal Title: Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology - Year 2018, Vol 4, Issue 3
Abstract
Introduction Habitual tobacco use is known to cause various health hazards by initiating oxidative stress through the release of free radicals The free radicals induce cellular damage that is reflected through alterations in antioxidant enzymes levels like superoxide dismutase SOD catalase CAT and glutathione peroxidase GPx within circulating erythrocytes Therefore it is important to estimate the erythrocytic SOD and GPx levels to assess tobacco induced oxidative stressAim The aim of the present study is to assess the effect of tobacco chewing and smoking on serum antioxidant enzymes superoxide dismutase and glutathione peroxidase levelsMaterials and Methods The present study comprised of 4 study groups including healthy control n25 tobacco smokers n25 tobacco chewers n25 and combination habit group n25 The case subjects were further subdivided depending upon the frequency of habits ie 10 timesday and 10 years and Result Mean erythrocytic SOD levels were significantly decreased in cases compared to control group whereas mean erythrocytic GPx level was significantly increased in cases compared to controls When SOD and GPx were compared for the frequency and duration of habits GPx levels were significantly increased among smokers who smoked Conclusions The present study confirmed the relationship between antioxidative enzymes activity oxidative stress and tobacco Frequency and duration of tobacco consumption were shown to alter antioxidant enzymes levels Therefore estimation of these enzyme levels will help in early intervention of tobacco habit by patient education and motivation and can minimize the risk of tobacco induced lesions Keywords Tobacco Erythrocytic superoxide dismutase SOD Glutathione peroxidase GPx Oxidative stress
Authors and Affiliations
Swati Garg, Padma Pandeshwar, S. Padmashree
Keywords
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- EP ID EP479794
- DOI 10.18231/2395-6194.2018.0036
- Views 145
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