Estimation of Serum Uric Acid and Bilirubin in Breast Cancer
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 7
Abstract
Abstract: High level of serum uric acid is important in diagnosis, cancer risk, recurrence and medical management of breast carcinoma. Serum uric acid provides a primary defense against human cancer based upon its capacity to scavenge singlet oxygen and its capacity to inhibit lipid per oxidation. To estimate Level of Serum Uric acid and Bilirubin in Breast cancer patients. The study includes 50 patients of breast cancer of 20-70 year age group along with age and sex matched healthy control. Serum Uric acid and Bilirubin was estimated from all participant and obtained data were analysed statistically by calculating p-value. In results the mean uric acid level increases (8.6 +1.3) with S.D. in study population and found to be significant (p<0.050) when compared to healthy control group uric acid level (mean+S.D. = 4.9 + 1.6). Bilirubin level were found to be 0.93 + 1.4 (mean+S.D.) in breast carcinoma patients while in healthy it was 0.86 + 2.6 S.D.(mean+ S.D.) and showed insignificant correlation when compared with control group (p=0.86). in conclusion the increased uric acid level may be a diagnostic marker in breast carcinoma as well as it showed oxidative stress in breast carcinoma and role of uric acid as antioxidant. However bilirubin level within normal limits in both groups showed role of bilirubin insignificant in breast cancer. Keywords: Breast carcinoma, Uric acid, Bilirubin.
Authors and Affiliations
Dr R J Chhabra, Dr. Ketan Mangukiya, Mrs Neha Sharma, Miss Ritu Sharma
Keywords
Related Articles
- EP ID EP377449
- DOI -
- Views 117
- Downloads 0
Development and Validation of Dual Wavelength Spectrophotometric methods for Simultaneous Estimation of Ketotifen and Salbutamolin in Bulk and Pharmaceutical Dosage Form
To develop and validate a simple& accurate Spectrophotometry methods for simultaneous estimation of Ketotifen and Salbutamol in their combined pharmaceutical dosage form. Two simple, accurate, precise U.V Spectroscopy me...
Role of Antidiabetic Drug Metformin in Ovarian Cancer Cells in Vitro
Abstract:Ovarian cancer is one of the most common lethal gynecological malignancies. Despite an initial 70-80% response rate, most patients relapse within 1-2 years and develop chemo resistance. Tumor cells have the capa...
Assessment of acute and subacute toxicological profiles of the aqueous extract (decoction) from the leaves of Triclisia gilletii (De Wild.) Staner (Menispermaceae) in Wstar rats
Abstract: The present study was undertaken to evaluate the acute and subacute toxicity of the aqueous extract of Triclisia gilletii leaves in experimental animals. Wistar rats in acute toxicity were used and given single...
Phytopharmacological Review of Plumeria species
The various species of Plumeria are known to have medicinal properties and have a long history of use by indigenous and tribal people in India. The medicinal value of this Plumeria species in the treatment of a large nu...
Hepatoprotective Activity of Citrullus Lanatus Seed Oil on CCl4 Induced Liver Damage in Rats
Abstract – The present study aimed evaluate the protective effect of citrullus lanatus seed oil against CCl4 induced hepatic damage in rat. The hepatoprotective was on carbon tetrachloride induced hepatotoxicity in...