Estimation of Serum Uric acid, Creatinine, Total Cholesterol and LDL among Sudanese Using Atorvastatin Drug
Journal Title: Saudi Journal of Biomedical Research - Year 2018, Vol 3, Issue 2
Abstract
Abstract:Atorvastatin is lipid lowering drug use in different cases to prevent complications of hyperlipidemia by lowering lipid mainly affect cholesterol, but it also affect in concentration of other serum parameters such as uric acid and creatinine. Case-control study was conducted during the period between Marchs to May 2017, included 100 participants 60% cases and 40% control with age between (20-70) years. Case group included 62% female and 38% male, used different doses (10, 20 and 40 mg/day) and different durations using for variable conditions such as (DM, HTN or protection for risk of CVD). Control group was matched for cases group but not used any lipid lowering drugs. The result of this study showed that significant association between atorvastatin uses and decrease in UA, Cr, T.Chl and LDL (P-value: 0.000, 0.020, 0.015 & 0.018 respectively). Decrease in all parameters by increase dose but not significant only significant with dose 40 mg/day (p-value: 0.037, 0.044, 0.044 & 0.005 respectively). Decrease in Cr, TCh and LDL by increasing the durational of atorvastatin intake and concentration (P= 0.042, 0.001 & 0.000 respectively). Significant relation was detected between combination DM & HTN and increase UA (4.55±0.87) & Cr (0.69±0.16) (P-value: 0.032 & 0.015 respectively) no significant relation with T.Chl and LDL (P-value: 0.636 & 0.594 respectively). Significant decrease in UA, Cr, T .Cho & LDL mean concentration found among atorvastatin user and the dose 40mg/day is highly significant effect. No correlation between durational of atorvastatin used and the parameter concentration. A more research should be done to detect specific correlation between atorvastatin and this parameters. Keywords: Hyperlipidemia; Lipid lowering Drug (atorvastatin); Uric acid; Creatinine; Diabetes Mellitus (DM); Hypertension (HTN); Cardiovascular Disease (CVD).
Authors and Affiliations
Ahmed O. Abuelhassan, Abdelkarim A. Abdrabo, Abdelgadir Eltom
Keywords
Related Articles
- EP ID EP397838
- DOI -
- Views 90
- Downloads 0
The Factors Affectıng the Occupational Health-Safety Practice of the Hospital Workers with the Knowledge-Attention Status
Abstract:Occupational health and safety in the health sector has gained more importance over recent years. Education and work in hospitals that are involved in the 'very dangerous workplaces' class are valuable in suppor...
Effects of Burning and Time Taken from Cut to Mill on Cane Deterioration and Dextran Levels in Sugars and Molasses from HalfaAlgadidah Sugar Factory, Sudan
Abstract:Comprehensive chemical analysis was carried out for products of sugarcane in an attempt to find the effect of burning and the time taken from cut to mill on cane deterioration and dextran levels in sugars and by...
Evaluating of the Drinking Water Quality in Kassala-City, Sudan
Evaluating of the Drinking Water Quality in Kassala-City, Sudan Abstract:Contaminated water may affect the health of millions of residents in the world.The main objective of this research work is to evaluate the drinking...
Comparative Study of Antioxidant Activity and Hepato-Protective Effect of Extracts of Tetracarpidiumconophorumand Dacryodesedulison Sodium Arsenate Exposed Rats
Abstract:This study comparatively evaluated the in vitro antioxidant activity and the hepato-protective effect of extracts of two locally consumed fruits, Dacryodesedulis(African pear) and Tetracarpidiumconophorum (Afric...
Hormonal Therapy in Breast Cancer: Consideration of Pharmacogenetics
Abstract: Hormonal imbalance in postmenopausal women makes them susceptible to various menopausal symptoms and hormonal replacement therapy (HRT) is the treatment option for them. However, various concerns are involved w...