ESTROGENIC ACTIVITY OF MUCUNA PRURIENS IN SWISS ALBINO MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
Various parts of Mucuna pruriens have been claimed to be useful in conditions like dysmenorrhoea, amenorrhoea, menorrhagia, infertility in females and lack of libido, stamina, sex drive, spermatorrhea, impotency in males. In present study, estrogenic activity of M. pruriens in mice was studied. The ovariectomy of selected mice was performed by flank method under mild ether anesthesia. Drugs under study were administered for fourteen days. One day after the administration of last dose, at necropsy, uteri were isolated, squeezed and weighed, under moist condition (freshly) for Assay of water uptake and under dehydrated condition for uterine weight assay. In present study, significant uterine weight gain was observed in moist and dry condition which might be due to the presence of estrogenic activity in the plant M. pruriens which was administered in the ethanolic extract form to the mice. Thus, it can be concluded that, the M. pruriens posses a good estrogenic activity.
Authors and Affiliations
Sushant Parekar , Arju Somkuwar
Keywords
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