Ethanol withdrawal-induced depressive symptoms in animals and therapeutic potential of sigma1 receptor ligands.

Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 6

Abstract

Clinical evidence has indicated a high degree of comorbidity of alcoholism and depression. Manifestation of the depression symptoms during abstinence increases the likelihood of relapse and indicates a worse prognosis in terms of treatment outcome. The depressive symptoms may be alcohol independent or alcohol induced. In this paper, only the ethanol-related depression is the focus of interest. In preclinical studies, some models of depressive-like symptoms induced by chronic alcohol treatment and withdrawal were proposed. In this minireview, the results concerning the depression-like behavior and some accompanying biochemical changes induced by prolonged ethanol exposure and its cessation in rats and mice were summarized. Moreover, the therapeutic potential of sigma1 receptor ligands for the treatment of depression disorder induced by ethanol abuse and withdrawal is discussed.

Authors and Affiliations

Grażyna Skuza

Keywords

Related Articles

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

Background: Organic cation transporter 1 (OCT1, SLC22A1) is a membrane transporter that is important for therapeutic effect of the antidiabetic drug metformin. Its liver-specific expression in hepatocytes is strongly con...

Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.

Hypertension is a well established risk factor for the development of cardiovascular diseases and increased mortality. This study was performed to investigate the effects of the administration of L-carnitine or mildronat...

Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT(6) receptor antagonist SB-399885 in rats.

The mechanism of the antidepressant-like activity of the selective 5-hydroxytryptamine(6) (5-HT(6) receptor antagonist N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide (SB-399885) was st...

Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats.

Background: Epileptogenesis is regarded as a complicated and relatively poorly understood phenomenon. Some of immediate early genes (IEGs) as egr1 (zif268) or arc (arg3.1) are believed to play an important role in the pr...

Effect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients.

Background: Warfarin, an oral anticoagulant is used in patients who are at increased risk of developing blood clots. The management of warfarin therapy is challenging because it shows large inter and intra individual var...

Download PDF file
  • EP ID EP115744
  • DOI -
  • Views 87
  • Downloads 0

How To Cite

Grażyna Skuza (2013). Ethanol withdrawal-induced depressive symptoms in animals and therapeutic potential of sigma1 receptor ligands.. Pharmacological Reports, 65(6), 1681-1687. https://europub.co.uk/articles/-A-115744