Ethanolic Extract of Ocimum Grattissimum Leaves (Linn.) Rapidly Lowers Blood Glucose Levels in Diabetic Wistar Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 4
Abstract
Background: The present study was undertaken to investigate the effects of ethanolic extracts of Ocimum gratissimum leaves on blood glucose and weight parameters in streptozotocin induced diabetic Wistar rats. Aim: The aim was to provide information on the glucose lowering potentials of ethanolic extract of Ocimum gratissimum and also compare this effect with that seen following administration of metformin. Material and Methods: Thirty adult male rats aged between 6- 8 months weighing between 180 and 200 g were randomly divided into five groups (A, B, C, D and E) of six rats each. Group A was the control, group B received oral Metformin at 25 mg/kg, while animals in group C, D and E received Ocimum gratissimum at 400, 600 and 800 mg kg-1 body weight orally, treatment period was for 28 days. Fasting blood glucose and weight were measured weekly throughout the treatment period. Statistical analysis was carried out using a one way ANOVA followed by the Student-Newman-Keul’s test. Results: Results showed that ethanolic extract of Ocimum gratissimum reduced blood glucose levels and body weight significantly all through the treatment period, that these effects were more rapid with increasing doses of the extract, and the glucose lowering potential of Ocimum gratissimum was comparable to that seen following administration of metformin. Conclusion: In conclusion, this study showed that ethanolic extract of Ocimum gratissimum has a more potent antihyperglycaemic effect than metformin at the doses studied, however, the mechanism(s) by which it does this is not yet established, we hope to do this in our subsequent studies.
Authors and Affiliations
Adejoke Y. Onaolapo| Department of Human Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria, Olakunle J. Onaolapo| Department of Pharmacology and Therapeutics, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria, Stephen A Adewole| Department of Anatomy and Cell Biology, Obafemi Awolowo University, Ile –Ife, Osun State , Nigeria
Keywords
Related Articles
- EP ID EP8823
- DOI 10.3889/MJMS.1857-5773.2011.0172
- Views 330
- Downloads 14
Combination of Left Ventricular Noncompaction and Bicuspid Aortic Valve in 19-Year-Old Male: A Case Report from Republic of Macedonia
Background: Noncompaction of the ventricular myocardium is a rare, unclassified cardiomyopathy due to an arrest of myocardial morphogenesis. The characteristic echocardiographic findings consist of multiple, prominent...
In Vitro Inhibition of Growth and Aflatoxin B1 Production of Aspergillus Flavus Strain (ATCC 16872) by Various Medicinal Plant Essential Oils
The hazardous nature of aflatoxins to human and animals necessitate the need for establishment of control measures. The objective of this study was to evaluate the inhibition of growth and aflatoxin production of Asper...
Contribution of Maternal Demographic and Medical Factors to the Risk of Prematurity in Qom Hospitals
Background. Prematurity remains the most significant cause of neonatal morbidity and mortality. Knowing which group of women is at risk for developing preterm labor will define a Target population for better prenatal c...
Synovial Sarcoma of the Liver – A Case Report
We report a case of synovial sarcoma of liver in a 44 year old man, presented as a tumor mass in left hepatic lobe. The patient was admitted at the hospital with clinical symptoms of acute abdomen and severe pain in th...
Antimicrobial Susceptibility of Bacteria Isolated from Newborns with Suspected or Confirmed Necrotising Enterocolitis
Aim. This audit aimed to identify which bacteria were associated with necrotising enterocolitis (NEC) and determine their antibiotic sensitivities. Methods. A retrospective audit of all infants with a diagnosis of susp...