Etiological characteristics of viral gastroenteritis in pediatric inpatients under five years old in Shanghai， 2021‒2022
Journal Title: Shanghai Journal of Preventive Medicine - Year 2024, Vol 36, Issue 2
Abstract
Objective To investigate the changes in the pathogen spectrum of viral diarrhea in local pediatric inpatients as well as any variations in genotypes of major pathogens during the COVID-19 control period.Methods Fecal samples were collected from the children <5 years who were hospitalized due to acute gastroenteritis in a pediatric hospital in Shanghai. PCR test was carried out to detect rotavirus， norovirus， sapovirus， astrovirus and enteric adenovirus， and then genotyping was performed for major pathogens.Results Out of 546 samples， 37.55% tested positive for virus with the following positive rate ranking： norovirus GⅡ （22.16%）， group A rotavirus （16.12%）， astrovirus （2.93%）， enteric adenovirus （2.38%）， sapovirus （0.92%） and norovirus GⅠ （0.18%）. The predominant genotype within norovirus GⅡ were GⅡ.4［P31］ and GⅡ.4［P16］ with a proportion of 24.79% and 14.05% respectively. The detection rate of GⅡ.4［P31］ dropped significantly over the 2-year period （χ2＝16.140，P<0.001）. In addition， an emerging rotavirus genotype G8P ［8］， which was rarely found nationally， was discovered for the first time locally with an increasing proportion， accounting for 7.95% of all rotavirus positive cases. Phylogenic analysis demonstrated that the representative strains of this genotype were genetically closer to the DS-1-like G8P ［8］ strain found in Southeast Asia.Conclusion The changes in the prevalence of various norovirus genotypes together with the emergence of rare rotavirus genotype in the local area illustrate the importance of continuous monitoring of viral diarrhea and genotyping of key pathogens. Increased local activity of the rare genotype also adds new parameters in the efficacy evaluation of marketed vaccines and development of potential new vaccines in near future.
Authors and Affiliations
KUANG Xiaozhou,XIAO Wenjia,PAN Hao,CHEN Min,TENG Zheng,
Keywords
Related Articles
- EP ID EP741998
- DOI -
- Views 14
- Downloads 0
Trends in antimicrobial use and hospital infection incidence among inpatients
Objective To understand the use of antibiotics in inpatients and the incidence and trend of hospital infections， to explore the implementation effect of comprehensive management measures， and to provide reference for h...
Incidence and influencing factors of postpartum depression and anxiety among 2 490 puerpera in Urumqi in 2020
ObjectiveTo investigate the incidence and influencing factors of postpartum depression and anxiety in Urumqi during the coronavirus disease ï¼COVID-19ï¼ epidemic period in 2020.MethodsResearch subjects were the parturi...
Reasons and achievement of Chinese dynamic zero-COVID-19 strategyâs consistency
COVID-19 has caused more than 600 million casesï¼ more than 6 million death and mortality of 1.24% worldwide. One out of every six people caught COVID-19 at the 5th wave of expansionï¼ having a mortality of 15 per 10 t...
Analysis of the current status of health facility development in Shanghai
Objective To compare the development status of health facilities in different regions （non-agricultural and agricultural districts）and different types across four dimensions： organizational management， health environ...
Relationship between plasma SP-A expression level and disease stage in silicosis patients
Objective To investigate the relationship between plasma surfactant protein⁃A （SP⁃A） expression level and silicosis progression， and to provide early evidence for exploring whether SP⁃A can be used as a biomarker for...