Etiological Evaluation of Congenital Hypothyroidism in Cases Referred from the National Screening Program
Journal Title: The Journal of Pediatric Research - Year 2021, Vol 8, Issue 1
Abstract
Aim: To evaluate cases referred from the congenital hypothyroidism (CH) new-born screening program. Materials and Methods: One hundred and thirty-five cases which were referred between January 2017 and July 2019 were included in the study. Results: Fourty eight of 135 cases (35.6%) were diagnosed as CH. The mean onset of treatment was 17.31±9.92 days. Clinical findings suggesting hypothyroidism were detected in 27 patients (56.2%) and goiter was detected in 2 patients (4.1%). According to imaging findings, 16 (35.5%) patients were diagnosed as dysgenesis, [1 (2.2%) as agenesia, 3 (6.7%) as ectopia, and 12 (26.6%) as hypoplasia], 11 were diagnosed as dyshormonogenesis (24.5%), and 18 were diagnosed as eutopic thyroid (40%). The mean levothyroxine dose was 12.7±2.5 mcg/kg/day and the mean onset of treatment in 30.4% of diagnosed patients was within the first 14 days and 93.3% were within the first 30 days. Conclusion: Dysgenesis and dyshormonogenesis are the most common detectable causes of CH. The normal localization of the thyroid gland in about half of the patients suggests that transient causes of CH may be more common than expected. Considering that only 1/3 of the patients were treated in the first 2 weeks, it was thought that the referral of patients is still an important problem and it should be done more promptly.
Authors and Affiliations
Deniz Tanyeri, Ayşe Anık, Arzu Cengiz, Yasemin Durum Polat, Tolga Ünüvar, Ahmet Anık
Keywords
Related Articles
- EP ID EP693584
- DOI 10.4274/jpr.galenos.2020.68736
- Views 95
- Downloads 0
Infantile Colic in Infants Aged One-Six Months and the Practices of Mothers for Colic
Aim: The aims of this study were to explore the infantile colic in infants from 1-6 months of age, and the mother’s practices to eliminate colic and the relationships between infantile colic scores and sample characteris...
Rapid Detection of Specific Gram-negative Microorganisms Causing Bloodstream Infections in Children with the Microarray Method
Aim: Bloodstream infections are serious conditions that can cause significant morbidity and mortality. Early recognition of the bacteria and targeted early treatment play an important role in prognosis. The Verigene Gram...
A Decline in Aminotransferase Activity Due to Lifestyle Modification in Children with NAFLD
Aim: As obesity rates in children and adolescents increase, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease affecting this organ. This study aimed to evaluate the effectiveness of lifes...
The Effect of Mother’s Lullaby on Preterm Infants’ Physiological Parameters
Aim: Inappropriate auditory stimulants lead to neonatal stress and changes in physiological parameters. Nowadays, particular emphasis is placed on the developmental aspects of the care of preterm infants. The lullaby is...
The Impact of e-Health Literacy on Health Promotion Behaviors of High School Students
Aim: The aim of this study was to investigate the effects of e-health literacy on health promotion behaviors on high school students. Materials and Methods: This descriptive, cross-sectional and relational study was con...