Etoposide induced hepatotoxicity- A rare case report
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 7
Abstract
: Seminoma is a malignant germ cell tumor usually affecting the testicles.Treatment usually requires removal of the involved testis. Chemotherapy is recommended for patients with stage IIC or stage III seminomas. Etoposide containing regimens are used for treatment of this cancer. Here is a case of seminoma testis with sickle cell trait developing liver injury after one month of intake of tablet etoposide50mg once daily. His bilirubin & alkaline phosphatase levels were significantly raised above normal limits after taking etoposide. After the drug was stopped patient`s bilirubin level started to decrease. Etoposide was replaced with carboplatin. Causality assessment using the WHO criteria showed that etoposide possibly caused this adverse reaction. Keywords:Seminoma,Epipodophylotoxin, Bilirubin, Alkaline Phosphatase
Authors and Affiliations
Dr. Kaustav Saha, Dr. RatnaAgrawal
Keywords
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