Evaluating FFA and UWF SS-OCTA abnormalities in X-linked retinoschisis: a cross-sectional study of 46 eyes
Journal Title: Eye Science - Year 2024, Vol 1, Issue 4
Abstract
[Aims] This study describes vascular abnormalities in X-linked retinoschisis (XLRS) using fundus fluorescein angiography (FFA) and ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA) to better understand the disease's vascular features and impact. [Methods] A retrospective cross-sectional study was conducted on 26 XLRS patients (46 eyes). A comprehensive ophthalmic examination was performed, including FFA and UWF SS-OCTA. FFA abnormalities were divided into peripheral schisis-associated and optic disc-associated types. [Results] The mean age of patients was 11.3±6.5 years. Macular schisis appeared in 97.8% of eyes, peripheral schisis in 89.1%, and peripheral bullous schisis (PBS) in 67.39%. Major vascular changes identified by FFA included dendritic capillary dilation/leakage (91.3%), internal residual vessel leakage (78.3%), and capillary dropout/ischemia (71.7%). Minor changes included zonal retinal pigment epithelium (RPE) proliferation (6.5%), bridging vessels (4.4%), and capillary sheathing (4.4%). peripapillary choroidal neovascularization (PPCNV) was noted in 10.9% and situs inversus of optic disc in 13.0% of eyes. Additionally, situs in versus of optic disc and zonal RPE proliferation were novel findings. Major FFA changes correlated with broader PBS (P=0.045) (P<0.001) (P=0.003). Clock hours of PBS were significant predictors for internal residual vessel leakage (OR = 0.30, P = 0.03). No significant correlation was found between gene mutation type and FFA abnormalities (P=0.539). [Conclusions] This study highlighted the significant prevalence (95.7%) of vascular abnormalities in XLRS and emphasized the importance of combining FFA with UWF SS-OCTA for comprehensive evaluation, enhancing the understanding of XLRS pathophysiology and aiding in targeted treatment approaches.
Authors and Affiliations
Linyan Zhang, Xiongze Zhang, Miner Yuan, Limei Sun, Xianghua Wu, Shuya Ke, Xiaoyan Ding
Keywords
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- EP ID EP768773
- DOI 10.12419/es24080801
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