EVALUATING THE BEST POLYETHYLENE GLYCOL AS SOLID DISPERSION CARRIER BY TAKING ETORICOXIB AS A MODEL DRUG
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: The main objective of the current research is focused in discovering the best polyethylene glycol (PEG) as solid dispersion carrier using etoricoxib (ECB) as a model drug. Methods: Varieties of PEG, namely PEG - 3350, PEG - 4000, PEG - 6000, PEG - 8000, and PEG - 20000, were evaluated as a carrier for making ECB solid dispersions. ECB:PEG was taken in the ratios of 1:1, 1:2, 1:4, and 1:6. The solid dispersions were prepared by microwave fusion method and compressed using 8 station tablet compression machine. The fabricated solid dispersion tablets were tested for physicochemical characteristics and drug release rates. The release of ECB from the prepared solid dispersions was further analyzed kinetically using the first order and Hixson-Crowell’s plots. Results: All the solid dispersion batches were shown satisfactory physicochemical characteristics. ECB solid dispersion batches with PEG - 6000 showed good solubility in distilled water (up to 2.29±0.01 μg/ml) and in 0.1 N HCl (up to 2.18±0.01 μg/ml) when compared with ECB alone (0.21±0.01 μg/ml and 0.32±0.01 μg/ml). The prepared solid dispersions with PEG 6000 are shown good ECB release. Conclusion: Among PEG carriers, PEG - 6000 was found to be the best carrier for increasing the solubility and release rate of ECB form the solid dispersions compared to PEG - 3350, PEG - 4000, PEG - 8000, and PEG - 20000.
Authors and Affiliations
HEMANTH A, HINDUSTAN ABDUL AHAD, DEVANNA N
PHYTOCHEMICAL EVALUATION, GC-MS ANALYSIS OF PHYTOACTIVE COMPOUNDS, AND ANTIBACTERIAL ACTIVITY STUDIES FROM LINUM USITATISSIMUM
Objective: The flaxseed or linseed (Linum usitatissimum) is a minor oil seed belonging to the family Linaceae and genus Linum, which has been used as a precious nutritional food grain and folklore medicine in human diets...
FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE TOPICAL GEL FOR WOUND INFECTIONS
Objective: The objective of this research work was to formulate and evaluate topical gel loaded with cefixime trihydrate, a third-generation cephalosporin antibiotic for the treatment of bacterial wound infections.Method...
A STUDY OF DRUG UTILIZATION PATTERN OF THE GERIATRIC PATIENTS IN THE DEPARTMENT OF GERIATRIC MEDICINE IN A TERTIARY CARE HOSPITAL IN ASSAM, INDIA
Objective: To investigate the drug utilization pattern and the prevalence of potentially inappropriate medications (PIMs) using updated AGS Beers criteria 2012 among the elderly patients who attended the geriatric outpat...
HISTOLOGICAL AND IMMUNOLOGICAL STUDIES ON THE PROTECTIVE EFFECT OF EUCALYPTUS CAMALDULENSIS AGAINST ROUNDUP-INDUCED HEPATOTOXICITY IN FROGS
Objective: Roundup (RUP) is a prominent utilized worldwide herbicide. Possible toxicity of RUP is a considerable debate. We studied the possible mode of RUP cytotoxicity and the antitoxic effects of Eucalyptus camaldulen...
A NEW ELECTROCHEMICAL SENSOR BASED ON MODIFIED CARBON NANOTUBE-GRAPHITE MIXTURE PASTE ELECTRODE FOR VOLTAMMETRIC DETERMINATION OF RESORCINOL
Objective: A new carbon nanotube (CNT)-graphite mixture paste electrode modified by Sodium dodecyl sulfate (SDS) surfactant (SDSMCNTGMPE) was prepared and applied for sensitive electrochemical determination of resorcinol...