Evaluating the Effect of Intravenous Clonidine and Dexmedetomidine on Haemodynamic Stress Response during Pneumoperitoneum in Laparoscopic Abdominal Surgeries
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
Laparoscopic surgeries are superior over open surgical procedures and former has now become the gold standard for cholecystectomy. Though laparoscopic procedures are more beneficial and have less complications rate but they are not free from all the complications. Pneumoperitoneum created during laparoscopic procedure by insufflattion of gases and its duration leads to blood pressure and heart rate changes. Many pharmacological agents are used to subside effect of pneumoperitoneum. Clonidine and dexmedetomidine are selective α- 2 agonists used for the same purpose. This randomized control study was conducted on 60 patients of ASA grade 1 and 2 after taking ethics committee approval. Group CL (n=30) clonidine is infused during the surgery and in group D (n=30) dexmedetomidine is infused during the surgery is infused. Diastolic and systolic blood pressure, mean arterial blood pressure and heart rate were measured throughout the procedure till 30 minutes after the procedure. Sedation score was also measured after the surgery. Effect of intubation and laryngoscopy induced stress response, creation of pneumoperitoneum, reversal of pneumoperitoneum and extubation was seen over heart rate, SBP, DBP and MAP in both the groups but was significantly less in the dexmedetomidine group(D) compared to the clonidine(CL) group showing better stability of the hemodynamic vitals in the patients given dexmedetomidine intraoperatively (P<0.05). Dexmedetomidine and clonidine both suppresses pneumoperitoneum induced hemodynamic instabilities in patients undergoing laparoscopic cholecystectomy under general anaesthesia but dexmedetomidine is better than clonidine.
Authors and Affiliations
Sandeep Kothiya, Nidhi Sharma
Keywords
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