EVALUATION AND ANALYSIS OF THE INVOLVEMENT OF A FIBRINOLYSIS INHIBITOR OF THE COAGULATION SYSTEM IN THE PROGRESSION OF CORONARY HEART DISEASE CHD
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 3
Abstract
Thrombin-activated Fibrinolysis inhibitor (TAFI), participates in the regulation of the balance between coagulation and fibrinolysis. High plasma levels of TAFI may therefore contribute to a hyperfibrinolytic condition and an increased risk of thrombotic disorders. Coronary stenosis is a consequence of the progression of atherosclerotic plaques, which is associated with a violation of fibrinolysis. Thrombin-activated fibrinolysis inhibitor (TAFI) and plasminogen activator 1 inhibitor (PAI-1) are fibrinolysis inhibitors whose levels depend on acquired conditions and polymorphisms. Therefore, our study is aimed at studying the association of TAFI gene polymorphism with the severity of coronary stenosis in patients with stable coronary artery disease (CAD). The methods that have recently appeared for determining alleles of polymorphic genetic markers using polymerase chain reaction will allow us to assess the genetic risk of developing cardiovascular pathology especially for the purpose of primary prevention of coronary heart disease, as well as to improve new approaches to individualization of therapy as a secondary prevention of the disease.
Authors and Affiliations
Nurillaeva Nargiza, Zоkirova Mubarakkhon, Khasanova Nargiza
Keywords
Related Articles
- EP ID EP714739
- DOI 10.5281/zenodo.7772057
- Views 57
- Downloads 0
IMPACT OF PRODUCTION ENVIRONMENT AND LABOR PROCESS FACTORS ON THE BODY OF FOUNDRY WORKERS
This article examines the production factors of working conditions at foundry workers’ workplaces, provides the actual values of the parameters under consideration and their impact on the body of workers. The most common...
MЕCHАNIZЕD АPPАRАTUS FОR CUTTING MЕLОN FRUIT INTО АNNULАR SLICЕS
Thе аrticlе is dеvоtеd tо thе mаthеmаticаl dеscriptiоn оf thе prоcеss оf cutting еlаstic-viscоus mаtеriаls оn thе еxаmplе оf а mеlоn fruit. А mеthоd fоr dеriving thеоrеticаlly cаlculаtеd еquаtiоns fоr dеtеrmining thе c...
STAGES OF SOCIAL-EMOTIONAL EDUCATION AND STRATEGIES OF SOCIAL AWARENESS AND INCLUSION IN THE DEVELOPMENT OF READING CULTURE IN CHILDREN
Establishing a friendly relationship with children through the culture of reading books, involving them in the educational process. Children's literature and social-emotional education. Social awareness, inclusion strate...
MARKET CONDITIONS AS ONE OF THE FACTORS INFLUENCING THE FORMATION OF CASH FLOWS OF AN ENTERPRISE
This article examines the impact of market conditions on the cash flow of enterprises. It highlights the importance of cash flow management to business success and explains how competition, economic changes and industry...
CRITERIA FOR THE EFFECTIVENESS OF RESEARCH AND PRODUCTION SPHERE
The article, based on scientific research of foreign experience and research work of domestic economists using the method of comparisons and mathematical calculations, substantiates the criteria that influence the format...