EVALUATION AND COMPARISON OF ANXIOLYTIC EFFECT OF FLAXSEED OIL AND PERILLA OIL IN MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
The Purpose of this study was to evaluate and compare the putative anxiolytic-like activity of Flaxseed Oil and Perilla Oil using elevated plus maze (EPM) and light-dark exploration test in mice. Flaxseed Oil is also known as linseed oil. Flaxseed Oil obtained from the dried ripe seeds of the Linum usitatissimum, (Linaceae). Perilla Oil is also known as Yegoma oil. It is obtained from seed of Perilla frutescens (Lamiaceae). Male mice were treated orally with the different doses of Flaxseed Oil (0.5-2.0 ml/kg), Perilla Oil (0.3-1.2ml/kg) and diazepam respectively, 1 hour before behavioral evaluation. Oral administration of 1.5 and 2.0ml/kg of Flaxseed Oil and 0.9, 1.2 ml/kg of Perilla Oil significantly (p<0.05) increased the number of entries and time spend in light arena of light-dark exploration test as well as these significantly (p<0.05) increased number of entries and time spent in open arm of elevated plus maze test. The anxiolytic effects of herbal oils compared with that of control group without any treatment and further, the results are quite comparable to diazepam (2mg/kg, p.o.). These results indicate that both oils have anxiolytic profile. The comparison between maximum significant effect of Flaxseed Oil and Perilla Oil at doses 1.5ml/kg and 0.9ml/kg respectively showed that Perilla Oil as more anxiolytic effect with low dose as compared with Flaxseed Oil.
Authors and Affiliations
Sandeep Kumar , Parminder Nain , Jaspreet Nain , Sunil Kumar
Keywords
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