EVALUATION AS TO WHETHER ALOCASIA FORNICATA CAN AUGMENT BLOOD GLUCOSE LOWERING EFFECTS OF GLIBENCLAMIDE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 11
Abstract
Background: Alocasia fornicata whole plant methanolic extract has been reported previously to improve oral glucose tolerance that is lower blood glucose levels in glucose-challenged mice. As such, it was of interest to examine whether the methanolic extract of whole plant can further improve oral glucose tolerance when administered concomitantly with a standard antihyperglycemic drug, glibenclamide. Methods: Oral glucose tolerance was determined through oral glucose tolerance test (OGTT) in mice. Results: Administration of methanol extract of whole plant (MEAF) at a dose of 400 mg per kg body weight to glucose-loaded mice reduced blood glucose level by 22.7%. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 41.8%. MEAF, when administered at doses of 200 and 400 mg per kg along with glibenclamide at 10 mg per kg, respectively reduced blood glucose levels by 42.1 and 43.1%. Conclusion: MEAF can augment the effect of glibenclamide but at a low extent.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP619144
- DOI -
- Views 149
- Downloads 0
PHARMACOKINETICS AND PK/PD MODELING OF AMOXICILLIN IN HUMAN MALE AND FEMALE VOLUNTEERS
The present study aimed to investigate the pharmacokinetic behavior in terms of Pharmacokinetic(PK)/Pharmacodynamic (PD) Modeling of amoxicillin in human male and female volunteers. For this purpose, ten healthy, adult m...
SYNTHESIS OF PYRIDOCOUMARIN DERIVATIVE BY THE APPLICATION OF PD-CATALYZED INTRAMOLECULAR HECK REACTION
Pyridocoumarin derivative have been synthesized by the application of Pd-catalyzed intramolecular Heck reaction. Here a synthetic protocol has been developed for the intramolecular Heck reaction of secondary and N-alkyla...
EFFECT OF FRACTIONS OF BRIDELIA MICRANTHA ON INSULIN RESISTANCE AND LIPID PROFILES IN HIGH SALT-INDUCED INSULIN RESISTANT RATS AND IDENTIFICATION OF PHYTOCONSTITUENTS BY GC-MS
This present study investigates the effect of fractions of Bridelia micrantha leaves on insulin resistance and lipid profiles in high salt-induced insulin resistant rats and its identification of phytoconstituents by Gas...
CYTOTOXIC AND WOUND HEALING POTENTIAL OF DMSO EXTRACTS OF PROPOLIS IN MDA-MB-231 CELLS
The aim of this study was to evaluate cytotoxic and wound healing effects of dimethyl sulfoxide (DMSO) extracts of Turkish propolis in MDA-MB-231 cancer cells. For the study of cytotoxic and wound healing effects of prop...
A COMPREHENSIVE REVIEW ON CHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF HIBISCUS SPECIES
Medicinal plants or botanical medicines have been used traditionally by mankind for the prevention and treatment of various ailments. The plants are the major source of various compounds that are widely used in pharma in...