Evaluation, Formulation and Optimization Study of Myrrh (Commiphora myrrha) Resin as Rate Controlling Excipient in Sustained Release Matrix Tablets of Theophylline
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 8, Issue 6
Abstract
Aims: To investigate myrrh (Commiphora myrrha) resin as a rate controlling excipient in sustained release matrix tablets of theophylline, and to optimize formulation and process variables of the tablet preparation using central composite design. Methodology: Wet granulation was employed for preparation of theophylline sustained release matrix tablets. Central composite design was used as an optimization tool having a total of 13 experimental runs with 5 central points. The myrrh resin amount (A) and compression force (B) were selected as independent variables. Cumulative % release of drug at 1 h, and 12 h and time to 50% drug release were taken as dependent variables. Results: The moisture content and total ash values of myrrh resin were found to be 4.67±0.58% and 0.24±0.05%, respectively. The angle of repose for all formulated granules were less than 30°. The hardness of different formulations were found to be between 89.8±2.86 and 133.7±3.53 N while all tablets have passed the friability test (<1%). Analysis of dissolution data of the formulations indicated that the best fitting model was the first order kinetics whereas the mechanism of drug release pattern followed anomalous or non-fickian diffusion. An optimum region of 24.98%, 91.22% and 2.86 h was obtained for cumulative % release of drug at 1 h, 12 h, and time to 50% drug release, respectively when 17.5% myrrh resin amount and 13.9 KN compression force was used. For the optimized formulation, the experimental values were found to be in close agreement with the predicted values (relative errors ranged between -4.496 and 4.814%) confirming the predictability and validity of the model. Conclusion: The results of this study showed that the myrrh resin from Commiphora myrrha can be used as a potential alternative rate controlling excipient for sustained release matrix tablet formulation.
Authors and Affiliations
Muluken Nigatu, Nisha Mary Joseph, Anteneh Belete
Keywords
Related Articles
- EP ID EP344336
- DOI 10.9734/BJPR/2015/20780
- Views 75
- Downloads 0
Spectroscopic Characterization and Antibiotic Study of Novel Compound Extracted from Curcuma longa (Turmeric)
Aims: To isolate and investigate the antibacterial potency of novel compound obtained from methanolic extract of Curcuma longa rhizome. Place and Duration of Study: Bio-inorganic and Materials Chemistry Research laborato...
Potential Antioxidant and Anti-Proliferative Activities of Biologically Active Marine Algae Extracts
Background: Marine microorganisms such as algae were identified a rich sources of biologically active compounds. This study was designed to explore the in vitro antioxidant, anti-apoptotic and anti proliferative activiti...
Kigelia africana Stem Bark, Fruit and Leaf Extracts Alleviate Benzene-induced Leukaemia in Rats
Aims: This study was aimed at evaluating the potential leukaemia chemotherapeutic activities of various extracts of Kigelia africana stem bark; fruit and leaf by using a benzene-induced model of leukaemia to validate its...
Bioactive Secondary Metabolites from Terrestrial Streptomyces baarnensis MH4
Aims: Isolation, screening and identification of potent bioactive compounds producing Streptomyces sp. from the terrestrial soil of Egypt. Fermentation study, product recovery, purification and its characterization was a...
TNF-α Inhibitor Treatment for Crohn’s Disease: Comparative Review of Post Therapy Malignancy between Infliximab and Adalimumab
The association between chronic inflammatory disease and cancer has been well established through years of research. In corollary, progressive resistance to chimeric monoclonal antibodies has been reported in literature....