Evaluation of α-glucosidase inhibition and antioxidant potential of Acacia modesta root bark
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 4
Abstract
The α-glucosidase inhibition and antioxidant potential of dichloromethane and methanolic extracts of Acacia modesta root bark were evaluated to provide basis for isolation and structure elucidation of bioactive compounds. In α-glucosidase inhibition assay, dichloromethane and methanolic extracts exhibited inhibitory activity of 98.9 % and 99.9 % with IC50 of 6.8 μg/ml and 1.2 μg/ml respectively. The results were compared with standard, acarbose, which showed 59.1 % inhibition with IC50of 540 μg/ml. While antioxidant assay results indicated that both dichloromethane and methanolicextractswere active with percentage radical scavenging activities of 76 % and 88 % respectively. IC50 values were also calculated which were 283.33 μg/mlfor dichloromethane extract and 236.49 μg/ml for methanolic extract. Ascorbic acid was used as standard. These results confirm that Acacia modesta root bark extracts possess α-glucosidase inhibitors and antioxidants, thereby providing worthy justification for isolation of novel bioactive compounds.
Authors and Affiliations
Wajid Sarwar*| Faculty of Pharmacy, Bahauddin Zakariya, University, Multan-60800, Pakistan., Bashir Ahmad Chaudhry| Faculty of Pharmacy, Bahauddin Zakariya, University, Multan-60800, Pakistan., Muhammad Uzair| Faculty of Pharmacy, Bahauddin Zakariya, University, Multan-60800, Pakistan., Muhammad Khurm| Faculty of Pharmacy, Bahauddin Zakariya, University, Multan-60800, Pakistan., Majid Manzoor| Faculty of Pharmacy, Bahauddin Zakariya, University, Multan-60800, Pakistan.
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