Evaluation of Acute and Subacute toxicity of Siddha herbal formulation Pungampoo chooranam
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
The Siddha system of medicine was not a discovery but a gradual evolution during successive periods of history by sages of South India called as Siddhars. Even though the materials used as drugs by Siddhars could be classified into herbal, inorganic substances and animal products great emphasis was given to herbs. Pungampoo Chooranam is one such herbal formulation consisting of flowers of single herb Pongamia pinnata. Although this herbal formulation has been indicated for the treatment of Diabetes mellitus in the Siddha classical literature Boga Munivar Vaithiyam – 700, its scientific data on its safety profile is still deficient. So the present study was performed to evaluate the toxicological potential of Pungampoo Chooranam. In acute oral toxicity study, Pungampoo Chooranam was administered at 2000mg/kg orally and animals were observed for toxic signs at 30 min, 1, 2 and 4 hours and thereafter once a day for the next 14 days. In repeated dose-28 day toxicity study, the animals were divided into three groups of 6 animals each consist of 3 male and 3 female rats. Group-1 animals received saline 5 ml/kg b.w (p.o). Group II Animals received low dose of test drug Pungampoo Chooranam 200 mg/kg (p.o). Group III animals received high dose of test drug 400 mg/kg (p.o) once daily for 28 days respectively. The study results showed that neither the acute toxicity study of Pungampoo Chooranam at the dose level of 2000mg/kg nor the repeated dose study did not produce any toxic sign or mortality during study. In repeated dose toxicity study, no significant changes were observed in the haematological and biochemical parameters, relative organ weight, gross necropsy and histopathological examination with Pungampoo Chooranam treatment. The Results of the present study suggest that LD50 of Pungampoo Chooranam >2000mg/kg.
Authors and Affiliations
J. Nisha
Keywords
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- EP ID EP243590
- DOI 10.9790/0853-1610047783
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