Evaluation of Addition of Low Dose Midazolam to a Mixture of Low Dose Ketamine and Hyperbaric Bupivacaine Given in Subarachnoid Block in Patients Undergoing Lower Limb Orthopaedic Surgery
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Background: Dr Bion used Ketamine first time intrathecally in patients wounded during war time. Intrathecal ketamine produced significant analgesia with stable haemodynamics. Combination of intrathecal Ketamine and Midazolam with Bupivacaine might have the advantages of Stable haemodynamics, prolonged duration of analgesia, synergism could reduce dose requirements, increase therapeutic index and reduce toxicity. Aims and Objectives: To evaluate addition of low dose Midazolam to a mixture of low dose Ketamine and Hyperbaric Bupivacaine in subarachnoid block in patients undergoing lower limb orthopedic surgery to study spinal blockade characteristic, duration and quality of analgesia and side effect profile in addition to post operative analgesia. Materials and Methods: A randomized study was carried out in the Department of Anaesthesiology, Govt. Medical College and SSG Hospital, Baroda between the periods of July 2009 to Feb 2010 with 60 patients, 30 in each group of both sexes. Results and Conclusions: Combination of Ketamine in low dose with Bupivacaine provides stable haemodynamics without any behavioural and central side effects. Addition of Midazolam in low dose to a mixture of low dose Ketamine and Bupivacaine when given intrathecally prolongs the duration of surgical anaesthesia and pain free interval without affecting the other parameters and complications of subarachnoid block
Authors and Affiliations
Dr Jalpa C. Balat
Study of Thyroid Profile in Patients with Sepsis
Background: Thyroid hormone abnormalities are frequently encountered in patients with sepsis, sepsis is important cause of death in developing countries. The aim of study is to analyze thyroid profile in sepsis patients...
Sonographic Evaluation of Endometriosis
Abstract
Root Resorption with Orthodontic Intrusion Review
AIM AND OBJECTIVE: This article reviews root resorption with micro implant assisted intrusion BACKGROUND: Orthodontic intrusion is a common treatment approach in managing orthodontic esthetic and functional problems, inc...
Prevalence of Bacterial Vaginosis in Patients Attending in Tertiary Care Hospital at ESI-PGIMSR, Basaidarpur
Objective: The present study was undertaken to assess the prevalence of bacterial vaginosis (BV) and to estimate the prevalence of anaerobic organism in vaginal discharge of woman suffering from bacterial vaginosis. Mate...
Family Burden in Caregivers of Chronic Schizophrenia and Bipolar Affective Disorder – A Comparative Study
Introduction: Due to paucity of organised care, families have been part of mental health care all throughout the history of India. The primary objectives of the present study were to assess burden of Caregiver of Chronic...