Evaluation of an Independent Association between Homocysteine Levels and Coronary Artery Disease in Patients Undergoing Coronary Angiogram
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Majority of patients who experience a Coronary Artery disease event have one or more of the conventional risk factors for atherosclerosis and so do many people who have not yet experienced such an event. Thus models based on conventional risk factors have a lesser accuracy to be attributed as a sole risk factor, providing a stimulus to search for new factors to predict accurately the risk of CAD. In this regard newer risk factors like homocysteine, Lp(a), insulin resistances are the important ones . This particular study was done with reference to homocysteine levels and its quantitative detection in patients with a clinical diagnosis of CAD, who were willing to undergo a coronary angiogram with the aim of finding an independent association between homocysteine levels and coronary artery disease in these patients. The study was planned such that these patients were divided into 2 groups, one with angiographic evidence of CAD and the other without angiographic evidence, the baseline patient characteristics were similar in both the groups, plasma homocysteine levels were assessed in both groups and the conclusion was a statistically significant higher value of plasma homocysteine in the group with angiographic evidence of CAD compared to the one without angiographic evidence of CAD thus establishing the role of homocysteine as an important and independent contributor to the development of CAD.
Authors and Affiliations
Ajay Sharma, Abhinav Nair, Shashank Dixit, Harsha HB
Keywords
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