EVALUATION OF ANALGESIC ACTIVITY OF Hibiscus Schizopetalus BY CENTRAL AND PERIPHERAL MODELS
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 5
Abstract
Objective:The present study was aimed to evaluate the central and peripheral analgesic activity of ethanolic extracts of Hibiscus schizopetalus (EEHS) (Mast) Hook (Malvaceae) in Wistar rats. Methods: Rats weighing about 180 to 200 g were made into 4 groups of 6 animals each. Aspirin 100mg/kg was used as standard drug. Analgesic activity was evaluated by physical, chemical and thermal methods such as tail clip test, acetic acid induced writhing test and hot plate test at the doses 200 and 400 mg/kg of EEHS respectively. Results: The EEHS was found to be non-toxic up to doses of 2000 mg/kg. The EEHS revealed the presence of flavonoids, alkaloids, terpenes, saponins and glycosides in the phytochemical evaluation. The EEHS treated rats showed significantly increased basal reaction time in hot plate test (p<0.001) and in tail clip test (p<0.01) respectively, while in acetic acid method significant (p<0.001) reduction in a number of writhing was observed. The results were obtained in a dose-dependent manner. Conclusion: Preliminary phytochemical screening of the EEHS which may be responsible for analgesic activities through both by central and peripheral models.
Authors and Affiliations
prakash r, baseem . , nowreen fathima s, karthick k, devadass . , muralidharan. p
Keywords
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