EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Inflammation and pain are the most common health problems treated with traditional remedies which mainly comprise medicinal plants. A number of natural products are used in the traditional medical systems in many countries. An alternative medicine for the treatment of various diseases is getting more popular. Many medicinal plants provide relief of symptoms comparable to that of obtained from allopathic medicines. Therefore agents of natural origin with very little side effects are required as substitute chemicals therapeutics. The methanolic leaf extract of Cocculus hirsutus (100& 200mg/kg) Linn (Menispermaceae) was investigated for its analgesic and anti-inflammatory effects in laboratory animals. The analgesic activity of the methanolic leaf extract of Cocculus hirsutus was investigated by eddy’s hot plate model and acetic acid induced writhing in mice. Anti-inflammatory activity of Cocculus hirsutus was studied by both in-vitro and in vivo models. Human red blood cells membrane stabilization method was adopted for the in-vitro anti-inflammatory activity and for in-vivo, Carrageenan induced paw edema and cotton pellet induced granuloma in rats was employed. In eddy’s hot plate analgesic study, both the doses of Cocculus hirsutus showed significant (p<0.05 and p<0.01 respectively) analgesic activity. In acetic acid induced writhing model, the onset of writhing was delayed and duration of writhing was shortened by the methanolic extract of Cocculus hirsutus. In-vitro anti-inflammatory activity of the methanolic leaf extract of Cocculus hirsutus showed significant anti inflammatory activity in a concentration dependent manner. Cocculus hirsutus showed significant anti-inflammatory activity on both carrgeenan as well as cotton pellet induced granuloma models in rats. From the results, it was concluded that the methanolic leaf extract of Cocculus hirsutus possess analgesic and anti-inflammatory.
Authors and Affiliations
G. Sarvankumar, K. Rajesh, S. Sengottuvelu, D. Hareesh
Keywords
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