Evaluation of Analgesic and Central Nervous System Depressant Effects of Microcospaniculata Leaves Extracts on Swiss Albino Mice
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 8
Abstract
Abstract: The main objective of the study was to evaluate the possible analgesic and central nervous system (CNS) depressant effects of methanol (MMPL), petroleum ether (PMPL), chloroform (CMPL), dichloromethane (DMPL) and aqueous (AMPL) extracts of the M. paniculataleaves. Analgesic effect was evaluated by acetic acid induced writhing and hot plate methods at 50 and 100 mg/kg dose. The CNS-depressant effect was assessed by using open field, hole cross and head deep tests at 100 and 200 mg/kg dose. All the extracts had exhibited significant (Pb< 0.01, Pa < 0.001) analgesic and CNS depressant effects at dose dependant manner. AMPL showed maximum analgesic effect with 72.92% inhibition of abdominal writhing and 33.03% maximal possible effect (MPE) of paw licking time at 100mg/kg dose. On the other hand, CMPL had shown highest CNS-depressant effect with 93.80% inhibition in open field, 84.63% inhibition in hole cross and 81.54% inhibition (head deeping) in head deep test at 200mg/kg dose. Among the five extracts AMPL is a potent analgesics and CMPL is a potent CNS-depressant agents. These findings may unveil the efficiency of these extracts as analgesics and CNS depressant drug which may lead to develop a new phyto-medicine. Keywords: Microcospaniculata; Traditional medicine; Analgesic effect; CNS-depressant effect; Writhing
Authors and Affiliations
Md. Anamul Haque, Md. Nasrullah . , Md. Raihan Sarker, A. S. M. Monjur-Al- Hossain
Keywords
Related Articles
- EP ID EP388405
- DOI -
- Views 101
- Downloads 0
Dengue fever complicated with Non-STEMI
Abstract: Dengue is a vector born viral infection that belongs to family Flaviviridae. It is a single stranded RNA virus and endangers 2.5 billion people world wild. Dengue viral (DENV) infections cause a broad spectrum...
Anthelmintic Activity of Bark of Acacia nilotica Linnon Pheretima posthuma
Abstract:The aqueous and chloroform extracts of Acacia nilotica linn belonging to the family Fabaceae were evaluated for anthelmintic activity. The dried powder of Acacia nilotica bark was extracted and the activity was...
Prevalence of musculokseletal pain among dentist: a cross-sectional study
Abstract: Around the globe, occupational-related diseases are widespread and common. Posture during work and duty hours are the major risk factor in the development of musculoskeletal disorder. The rationale behind the s...
Rapid Determination of Fluoxetine Concentration in Human Plasma by Ultra Performance Liquid Chromatography
A simple, precise, and rapid ultra-performance liquid chromatography (UPLC) method for the determination of fluoxetine level in human plasma using clomipramine as an internal standard (IS) was developed and validated. Pl...
Study of StavudineMultiparticulate Floating Drug Delivery System Prepared by Emulsion Gelation Technique
Abstract: Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Prolonged gastric retention improves bioavailability, reduces drug...