Evaluation of Anti-anxiety Activity of Grangeamaderaspatana(L.)Poir. Extracts in Experimental Animals
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2017, Vol 0, Issue 0
Abstract
Grangeamaderaspatana (L.)Poiris a popular Indian medicinal plant belonging to Asteraceae family. This plant is commonly known as Madras Carpetandisgrown in wet places. It has long been used in traditional Ayurvedic Indian medicine for various diseases. A wide range of phytochemical constituents have been isolated from this plant. This plant is pharmacologically studied for oestrogenicity, antifertility, analgesic, anti-inflammatory, antiarthritic, cytotoxic, antioxidant, hepatoprotective, diuretic and antimicrobial activities.Despite the widespread uses of the plant, no scientific work is reported in the literature regarding the effect of G. maderaspatana against anxiety like states. Chloroform (200 mg/kg, 400 mg/kg) and methanol extracts (200 mg/kg, 400 mg/kg) of G. maderaspatanawere evaluated for anti-anxiety activity in mice using elevated plus maze apparatus. Among all these extracts, chloroform extract exhibited significant anti-anxiety activity at a dose of 400 mg/kg in mice with respect to control.The chloroform and methanol extract of Grangeamaderaspatana possess significant anti-anxiety activity due presence of terpenoids, steroids and saponin.
Authors and Affiliations
Tanvi Dodiya, Vineet Jain
Keywords
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