Evaluation of Anti-cancer potential effect of Chandamarutha chenduram on MCF-7 cell line.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2019, Vol 5, Issue 2
Abstract
Background: Breast cancer is second most common in women and accounts for 23% of all occurring cancers in women. Patients with breast cancer have increasingly shown resistance and high toxicity to chemotherapeutic drugs. chandamarutha chenduram is a metallic preparation used in siddha medicine for the treatment of tonsillitis, paralysis, arthritis, fever, ulcers, cancer especially breast cancer. Aim and Objective: The present study was to investigate the anti cancer activity of chandamarutha chenduram against MCF-7 cell lines was examined by MTT assay. Materials & Methods: The drug was prepared as per the method mentioned in the classical Siddha literature. The drug is subjected to the anticancer activity against MCF-7 cell line was examined by MTT assay. Results: The result obtained from the study reveals that the percentage of MCF7 breast cancer celline line viability decrease with increase in concentration of the test drug. Least viability of cell was observed at the concentration of 100µg/ml shows 8.33 ± 0.46%, followed by this 80µg/ml shows 13.84 ± 0.92%, similarly 40,20,10 and 5 µg/ml shows 24.29 ± 2.23, 31.98 ± 2.32, 37.52 ± 2.81 and 44.28 ± 1.84 % cell viability in MTT assay. The corresponding IC50 value was found to be 25.26 ± 9.00 µg/ml. Conclusion: From this study we conclude that siddha formulation chandamarutha chenduram having significant anticancer activity against MCF-7 cell lines and it might be good therapeutic value.
Authors and Affiliations
Mahalakshmi. V*1 , Iyswarya. S2 , Visweswaran . S3 Muthukumar N. J4 , Banumathi. V 5
Keywords
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- EP ID EP550352
- DOI 10.22192/ijcrms.2019.05.02.002
- Views 140
- Downloads 0
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