EVALUATION OF ANTI DIABETIC ACTIVITY OF MARSILEA MINUTA LINN AGAINST ALLOXAN INDUCED DIABETES IN ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
The present study was design with an aim to evaluate the Ethanolic leaf extract of Marsilea minuta Linn (EEMM). The study was performed on ethanolic extract of MM leaf in oral glucose tolerance test (OGTT) and alloxan-induced diabetes models in albino rats. Three weeks treatment of diabetic animals with EEMM (250 and 500 mg/kg) showed significant check in rise of blood glucose compared to untreated diabetic rats along with improved complete lipid profile. The fasting blood glucose, cholesterol, HDL cholesterol and serum triglyceride content were estimated in both normal and alloxan induced diabetic rats. The fasting blood glucose, cholesterol and serum triglyceride content were found to be significantly reduced (p<0.05) in EEMM treated rats and the extract also showed the potent elevation in the level of serum HDL cholesterol. On the basis of analysis of data obtained during the study, it may be concluded that EEMM leaf is having significant antihyperglycemic potential and can be further fractionated in order to get a responsible constituent for this very action.
Authors and Affiliations
S. Madhu, V. Kannabirran, P. Royal Frank, M. Reddy, N. Gnanasekar
Keywords
Related Articles
- EP ID EP98059
- DOI -
- Views 94
- Downloads 0
DHAATRI: AN UPDATED REVIEW WITH SPECIAL REFERENCE TO HUMAN MILK BANKING
In ancient science of Ayurveda the concept of dhaatri (a wet nurse) is mentioned by many Acharyas like Charaka and Sushruta and Kashyapa. In deficiency of breast milk, the concept of dhaatri-a wet nurse-to feed the baby...
A NOVEL VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF QUETIAPINE FUMARATE IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORMS: APPLICATION TO DISSOLUTION STUDY
A simple, specific, accurate, rapid, inexpensive isocratic Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the quantitative determination of Quetiapine Fumarate in p...
EVALUATION OF THE KNOWLEDGE OF PATIENTS, COMPLIANCE TO TREATMENT AND THE IMPACT OF PATIENT EDUCATION ON ASTHMA: A QUESTIONNAIRE BASED STUDY ON OUTPATIENT ASTHMATICS
The purpose of this study was to evaluate the patient knowledge of asthma, their compliance to treatment, providing patient education and evaluating the impact of education on asthma management. With this view an interve...
PROTECTIVE EFFECTS OF MELATONIN AGAINST IDIOSYNCRATIC LIVER INJURY IN RATS CHALLENGED WITH CHLORPROMAZINE AND LIPOPOLYSACCHARIDE
The episode of inflammation during drug treatment predispose animals to tissue injury, raising the possibility that presence or absence of inflammation is an important susceptibility factor for drug toxicity in human , a...
MOUTH DISSOLVING TABLETS: A FUTURE COMPACTION
An orally disintegrating tablet or mouth dissolving tablet (MDT) is a drug dosage form available for a limited amount of over-the-counter (OTC) and prescription medications. MDTs differ from traditional tablets in that t...