EVALUATION OF ANTI DIABETIC ACTIVITY OF MARSILEA MINUTA LINN AGAINST ALLOXAN INDUCED DIABETES IN ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
The present study was design with an aim to evaluate the Ethanolic leaf extract of Marsilea minuta Linn (EEMM). The study was performed on ethanolic extract of MM leaf in oral glucose tolerance test (OGTT) and alloxan-induced diabetes models in albino rats. Three weeks treatment of diabetic animals with EEMM (250 and 500 mg/kg) showed significant check in rise of blood glucose compared to untreated diabetic rats along with improved complete lipid profile. The fasting blood glucose, cholesterol, HDL cholesterol and serum triglyceride content were estimated in both normal and alloxan induced diabetic rats. The fasting blood glucose, cholesterol and serum triglyceride content were found to be significantly reduced (p<0.05) in EEMM treated rats and the extract also showed the potent elevation in the level of serum HDL cholesterol. On the basis of analysis of data obtained during the study, it may be concluded that EEMM leaf is having significant antihyperglycemic potential and can be further fractionated in order to get a responsible constituent for this very action.
Authors and Affiliations
S. Madhu, V. Kannabirran, P. Royal Frank, M. Reddy, N. Gnanasekar
Keywords
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