EVALUATION OF ANTI-DIABETIC ACTIVITY ON n-BUTANOL FRACTION OF LEAF METHANOLIC EXTRACT OF CURCULIGO ORCHIOIDES (AMARYLLIDACAE) IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Journal Title: International Journal of Pharmacognosy - Year 2018, Vol 5, Issue 3
Abstract
The aim of present study to evaluate anti-diabetic activity of methanolic extract n-butanol fraction of Curculigo orchioides (Amaryllidacae) against in streptozotocin induced diabetic rats. Fractions were administrated orally at 200 mg/kg and 100 mg/kg for 3weeks. The effects were compared with oral dose of 10 mg/kg of Glibenclamide. Blood glucose levels are determination by GOD-POD kit method. In the results, our study indicates that Curculigo orchioides n-butanol fraction of leaf methanolic extract exhibited significant antihyperglycemic activities in streptozotocin - induced hyperglycemic rats without significant change in body weight. And shows the values are given in average body weight (g) ± SEM for groups of six animals each. A) Normal saline. B) Normal saline + streptozotocin. Significance vs. Control group *P < 0.01. **P < 0.005, ***P < 0.0001.
Authors and Affiliations
Kanakam Vijayabhaskar
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