EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF SCOPARIA DULCIS LINN ON WISTER ALBINO RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The objective of the study was to find out the ethanolic extract of the leaves of Scoparia dulcis Linn for antidiarrhoeal effects on Wister albino rats. The extract was evaluated for castor oil- induced diarrhoea and intestinal transit in rats by charcoal meal. S. dulcis Linn. Significantly (p<0.05) and dosedependently reduced frequency of stooling in castor oil-induced diarrhoea and intestinal motility in rats. The oral LD50 values obtained were greater than 2000mg/ kg in Wister albino mice. These findings suggest that the ethanolic extract of the leaves of S. dulcis Linn may contain some biologically active ingredients that are useful for the treatment of diarrhoea in Indian herbal traditional medicine.
Authors and Affiliations
Amitabha Dey, Ghanshyam Panigrahi, Lokesh Deb, Kh. Nongalleima, Pratap Patra
Keywords
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