Evaluation of anti-hyperlipidemic activity of clerodendrum serratum linn on high cholesterol diet induced hyperlipidemia in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 2
Abstract
The main objective of the study was to investigate about the antihyperlipidemic activity of the ethanolic extract from the aerial parts of Clerodendrum serratum Linn (EECS). Qualitative analysis of the extract revealed that it contains glycosides, alkaloids, tannins, proteins, amino acids, phytosterol, steriods, terpenoids & saponins. Acute oral toxicity study was performed. Animals were divided into five groups. Normal control, positive control, Std-I-Rosuvastatin + 5% cholesterol diet, Extract of EECS-250 mg + 5% cholesterol diet, Extract of EECS- 500mg + 5% cholesterol diet for 12 weeks. Parameters considered for evaluation Weight gain ,Blood samples were collected, parameters such as serum lipid profile ( TC, TG, HDL-c, LDL-c, VLDL-c), Kidney parameters (Urea, uric acid, Creatinine) and antioxidant enzymes such as (SOD, GSH, Catalase) were analysed. Findings suggested that Clerodendrum Serratum Linn. is a potent drug for hyperlipidemia, the drug extract treated groups lowers TC, TG, LDL-c & VLDL-c and increases the levels of HDL-c and antioxidant enzymes such as SOP, GSH and Catalase in all high cholesterol treated groups. Kidney parameters such as urea, creatinine and uric acid levels were decreased in all EECS treated group.
Authors and Affiliations
P. K. Kasthuri P. K. Kasthuri
Keywords
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