EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF TILIACORA ACUMINATA EXTRACT IN RATS
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 10
Abstract
Inflammation is part of the body's immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of ethanol extract of Tiliacora acuminata stem and leaf was evaluated using the carrageenan-induced rat paw edema. The ethanol extract of stem and leaf of Tiliacora acuminata was injected at different doses such as 200 and 400 µg/kg body weights, and the study was compared with standard drug indomethacin (10 mg/ml). In rat paw edema model induced by carageenan the extracts were found to reduce similarly (p<0.001). The formation of edema at the 400 µg/ml dose level and showed 77.92% for stem and 84.37% for leaf respectively, inhibition of edema volume at the end of 3 h. These results suggest that Tiliacora acuminata has anti-inflammatory property comparable with those of standard drug and may be useful for the treatment of painful inflammatory condition.
Authors and Affiliations
V. R. Mohan et al.
Keywords
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- EP ID EP656866
- DOI 10.13040/IJPSR.0975-8232.10(10).4673-76
- Views 81
- Downloads 0
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