Evaluation of Anti-Inflammatory and Antioxidant Activities of Ethanolicand Palm Wine Extract of the Stems of Phragmantheracapitata (Sprengel) S. Balle (Loranthaceae) Collected on PsidiumguajavaL. in Cameroon
Journal Title: Haya: The Saudi Journal of Life Sciences - Year 2018, Vol 3, Issue 8
Abstract
Abstract: The objective of this study was to evaluate the anti-inflammatory and antioxidant activities of ethanolic and palm wine extract of Phragmantheracapitata stems widely used by traditional healers. Acute toxicity according to the OCDE Guideline 423 showed that the LD50 of ethanolic and palm wine extract was greater than 5000 mg/Kg body weight. Anti-inflammatory capacity was evaluated by hind paw oedema model using carrageenan-induced inflammation in rat. It has showed that palm wine and ethanolic extracts possessed a dose-dependent anti-inflammatory activity (at the first hour) with 21.47% and 41.24%, respectively, as a percentage inhibition for the 200 and 300 mg/Kg body weight of palm wine extract and 16.95% and 28.21% for the ethanolic extract of same dose as compared with 25.42% for aspirin. The phenol dosage by the Folin-Ciocalteu method showed that ethanolic extract (14420 mg EAA/g dry extract) had a high content relative to the palm wine extract (2570 mg EAA/g of dry extract ). The antioxidant capacity was evaluated by the diphenyl-picryl test (DPPH), where the ethanolic extract showed strong antioxidant activity with a EC50 of 0.0085 mg/mL when that of the wine extract was 0.049 mg/mL, after the ascorbic acid (standard) with 0.033 mg/mL.Ethanolic and palm wine extract of Phragmantheracapitata stems are non-toxic and have inflammatory and antioxidant activity that could justify its traditional use. Keywords: Phragmantheracapitata, ethanol, palm wine, anti-inflammatory, antioxidant.
Authors and Affiliations
EtameLoe Gisèle, Ngaba Guy Pascal, Kamdom Mariette, NnangaNga Emmanuel, Yinyang Jacques, OkallaEbongue Cécile, Ngoule Charles Christian, Ngene Jean Pierre, Tankeu Séverin Elisée
Keywords
Related Articles
- EP ID EP397829
- DOI -
- Views 146
- Downloads 0
Anti-arthritic activity of leaves and oil of Aquilaria agallocha
Abstract: The present study conducted for Aquilaria agallocha of family Thymelaeaceae for anti-arthritic activity. The ethanolic extract of Aquilaria agallocha (EEAA) leaves and the Aquilaria agallocha oil (AAO) from Hea...
Synthesis and Characterization of (2E) -1- [4- (2, 4-Dithio-3-Ethylimino -5- Substitutedimino -1, 3, 5- Triazino-6-Yl) Aminophenyl] -3- (3, 4-Dimethoxyphenyl) Prop -2- En-1-One
Abstract: Present research work comprises, isomerisation of series of (2E)-1-[4-(2-ethylimino-4-substitutedimino)-1,3,5-dithiazino-6-yl) aminophenyl]-3-(3,4-dimethoxy phenyl)prop-2-en-1-one (Ia-e) were successfully carri...
Chemical Composition and Antimicrobial Activity of the Essential Oils from Aquillaria malaccensis in Bangladesh
Abstract: Agarwood oil is a highly priced type of oil due to its unique aroma. Agarwood oil is widely used in perfume, medicine and cosmetic industries due to its unique properties and high medicinal value. The oil is ge...
Photochemical Analysis of the Extracts of Secondary Metabolites from Leaves of IrvingiaGabonensis(Bush Mango)
Abstract: Microorganisms are important sources of bioactive natural products with enormous potential for the discovery of new molecules for drug discovery, industrial use and agricultural applications. In this study, pho...
Antibacterial Activity of Actinomycetes Isolated from Different Habitats of Hadhramout- Yemen
Abstract:A total of 70 actinomycetes strains were isolated from dams and caves of Hadhramout –Yemen and screened for their anti-bacterial activity based on their color and activity against bacterial pathogens. Twenty iso...