Evaluation of Anti-inflammatory and Antisickling Potentials of Archidium ohioense (Schimp. ex Mull) Extracts
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 1
Abstract
The study investigated the possible anti-inflammatory and antisickling potential of a moss plant A. ohioense.The phytoconstituents of acetone, chloroform and ethylacetate extracts of the plant were analysed using standard methods. Membrane stabilizing, antisickling, xanthine oxidase and lipooxygenase inhibitory activities of the extracts of the plants on sickle and normal erythrocytes were conducted. Phytochemically, the ethylacetate, acetone and chloroform extracts of A. ohioense showed the presence of cardiac glycoside, flavonoids, saponin, steroid, alkaloids and triterpenes. The acetone and ethyl acetate extracts of the plant stabilized red blood cell membrane of normal and sickle erythrocytes at various concentrations except at 2.0 mg/ml while the chloroform extract exhibits profound protective effect on both normal and sickle erythrocytes at highest concentration used (2.0 mg/ml).All the A. ohioense extracts showed mild anti-lipoxygenase and xanthine oxidase inhibitory activities. As the concentrations of the A. ohioense chloroform and acetone extracts increased, the percentage inhibition of sickling significantly increased and compared favorably with Parahydroxybenzoic acid. These two extracts also demonstrated significant (p ≤ 0.0001) dose dependent increase in antisickling reversal activity. This study indicates that A. ohioense could be valuable source of anti-inflammatory and antisickling agents.
Authors and Affiliations
Akinpelu, Bolajoko Ayinke;, 2 Makinde, Amos Morakinyo, 3Amujoyegbe,Olayinka Olajumoke;, Isa, Musibau Olalekan;, Onwobiko, Victor Chinemerem;, Akinwotu, Akintunde Oluwadare, 2Oladimeji,Ezekiel Seun, Agbedahunsi, 3 JosephMorunfolu;, 1Oyedapo, Oluokun Oluboade
Keywords
Related Articles
- EP ID EP388196
- DOI 10.9790/3008-1201021826
- Views 45
- Downloads 0
Emergence of New Snail Species and Cercariae on Jakara Dam
Fresh water snails in Jakara dam were investigated for different types of cercariae. Snails were collected from different parts of the dam in Minjibir, Ugoggo and Gezawa local government area between October 2016 and Jan...
Molecular study of blaVEB-1 gene in Proteus mirabilis isolated from clinicalSamples from Baghdad City’s hospitals
From different hospitals in Baghdad city, 25 clinical isolates of Proteus spp. were collected from different clinical samples, all isolates were identified as Proteus mirabilis by using bacteriological and biochemical as...
Impact of oil effluent on the enzyme activity in blood serum of freshwater food fish Cirrhinus mrigala
The purpose of this study was to estimate the acute toxicity of oil effluent on Cirrhinus mrigala and to evaluate the lethal levels. The 120 hrs median lethal concentration of oil effluent were found to be 20ppt for Cirr...
Socio-Economic and Agricultural Factor In Control of Trypanosomiasis in Nigeria A Review
Trypanosomiasis is a widespread disease in the middle belt states and southern part of Nigeria. Socio-economic activities such as herding, fishing, crop-rotation, collection of fire wood predisposed inhabitant to the dis...
Prevalence of Rota Virus Detection by Reverse TranscriptasePolymerase Chain Reaction in Stool from Children Fewer Than Five Age With Acute Diarrhea in Diyala Province in Iraq
The present study was conducted for the period from 1/6/2016 to 20/1/2017 in Baquba city. The study aimed to detection of rotavirus in stool specimens of children fewer than five age and also explore the effects of certa...