Evaluation of Anti-theilerial Activity of A lipophilic Root Bark Extract of Stereospermum kunthianum against Theileria Parva
Journal Title: International journal of Emerging Trends in Science and Technology - Year 2014, Vol 1, Issue 4
Abstract
Naphthoquinones are common compounds found in several species of Bignoniaceae and exhibit anti plasmodial activity hence providing leads for discovery and development of anti theilerial drugs. This study has established the presence of naphthoquinones in the leaf, stem bark and root bark of S. kunthianum for both the hydrophilic and lipophilic extracts and established the anti theilerial activity of the lipophilic root bark extract. Sixteen unknown naphthoquinones in both the lipophilic and hydrophilic extracts of the leaf; stem bark and root bark of S. kunthianum were screened by Thin layer chromatographic technique. The lipophilic root bark extract of S.kunthianum caused death of macroschizonts of T.parva with 18 % mean percentage activity at a start experimental dose of 1 µg/L. The mean percentage activity against macroschizonts of T. parva increased with increase in the concentration of the lipophilic root bark extract of S. kunthianum. The in vitro Median Effective Concentration, EC50 of 1.585µg/L as compared to the reported EC50 of 0.3 µg/L for Buparvaquone, a known hydroxy naphthoquinone used in the treatment of ECF, was obtained for the lipophilic root bark extract of Stereospermum kunthianum against Theileria parvaby linear regression analysis.
Authors and Affiliations
S. LUTOTI
Keywords
Related Articles
- EP ID EP220469
- DOI -
- Views 114
- Downloads 0
A New Technology for Ac-Side Cascaded H-Bridge Cells for Multi-Level VSC-HVDC Transmission System
The VSC based HVDC transmission system offers the operational flexibility in terms of active and reactive power control, in addition to improved AC fault ride-through capability. The proposed converter offers a unique fe...
Design of Virtual Oscilloscope Using Labview
LabVIEW is a Graphical Programming Language that uses inbuilt modules and functions instead of complicated code. We can use a LabVIEW With little knowledge of programming language. We build a user interface with a set of...
Contextual Array Kernel P System
In this paper we consider the contextual way of handling array objects in Kernel P Systems.We generate some languages in contextual array Kernel P systems.Hollow rectangles and squares are also generated using contextual...
Symmetry Techniques and Generating Functions for Basic Analogue of Fox's H-Function
The objective of this paper is to establish the q-recurrence relations, q-difference equations for basic analogue of Fox's H-function and then obtain the canonical equation associated with each family of multivariable q-...
Web Page Categorization Based on Neurons
Contemporary web is comprised of trillions of pages and everyday tremendous amount of requests are made to put more web pages on the WWW. It has been difficult to manage information present on web than to create it. Web...