EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF ABUTILON INDICUM 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3

Abstract

The present study was undertaken to evaluate the anti-ulcer properties of Abutilon indicum (AI). Ethanolic (AIE) and aqueous extracts (AIA) of AI were studied for their ability to inhibit the gastric lesions in pylorus ligation, aspirin and alcohol induced ulcer models in rats. In addition their effects on pH, wall mucus, total acidity and gastric acid output were recorded. The test drugs in the dose of 200 mg/kg were administered twice daily orally at 10:00 h and 16:00 h respectively for five days for gastro protective studies. Ranitidine was used as reference drug. Ethanolic and aqueous extracts of Abutilon indicum significantly inhibited the gastric lesions induced by pylorus ligation, aspirin and alcohol. The gastric volume and total acidity were found to be significantly reduced while the gastric pH and mucus contents were found to be increased as compared to control group. The present findings suggest that the antiulcer properties of Abutilon indicum may be due to its effect on both offensive and defensive factors. These results support the ethno medical uses of Abutilon indicum in the treatment of ulcer.  

Authors and Affiliations

Satish Sharma , Seshasai Sharma , Vipin Saini , Sharmistha Mohapatra

Keywords

Related Articles

EFFECTS OF ETHANOL DURING GIARDIASIS IN SHEEP INTESTINE 

Infections with Giardia lamblia are one of the most common intestinal maladies in the world. These infections can lead to acute diarrhea, cramps, and nausea, although asymptomatic infections are the most common. Although...

COMPARATIVE STUDY ON EFFECT OF SOLID DISPERSION TECHNIQUES FOR ENHANCEMENT OF DISSOLUTION RATE OF PIOGLITAZONE HCl 

Pioglitazone hydrochloride is a novel antidiabetic drug in thiazolidinediones group and it improves insulin sensitivity in insulin resistant patients. One of the major problems with this drug is its low solubility in bio...

AN OVERVIEW ON OPTIC NEURITIS 

Optic neuritis is a serious condition which typically involves the young adult population. Years ago it was thought that one third of optic neuritis patients would go on to have neurological symptoms from multiple sclero...

SELECTIVE AND DIRECTIONAL INFLUENCE OF BOUGAINVILLEA SPECTABILIS ON ANODIC ELECTROPHORETIC PROTEINS AND M-ISOZYMES OF LDH IN SEMEN OF MICE IN RELATION TO FERTILITY CONTROL  

The present study investigate the effects induced by the administration of the aqueous leaf extract of Bougainvillea spectabilis at the doses of 0.1 ml (800mg/kg/BW/day) on male mice for 10 to 50 days. This treatment cau...

AYURVEDIC APPROACH FOR CONCEIVING A HEALTHY PROGENY 

The medical world is really concerned about the increasing rate of congenital imperfections in the new born, which is posing confront to the aim of a healthy humanity. These congenital defects are seen as minor, major, a...

Download PDF file
  • EP ID EP93266
  • DOI 10.7897/2230-8407.04350
  • Views 96
  • Downloads 0

How To Cite

Satish Sharma, Seshasai Sharma, Vipin Saini, Sharmistha Mohapatra (2013). EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF ABUTILON INDICUM . International Research Journal of Pharmacy (IRJP), 4(3), 233-236. https://europub.co.uk/articles/-A-93266