EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF ABUTILON INDICUM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
The present study was undertaken to evaluate the anti-ulcer properties of Abutilon indicum (AI). Ethanolic (AIE) and aqueous extracts (AIA) of AI were studied for their ability to inhibit the gastric lesions in pylorus ligation, aspirin and alcohol induced ulcer models in rats. In addition their effects on pH, wall mucus, total acidity and gastric acid output were recorded. The test drugs in the dose of 200 mg/kg were administered twice daily orally at 10:00 h and 16:00 h respectively for five days for gastro protective studies. Ranitidine was used as reference drug. Ethanolic and aqueous extracts of Abutilon indicum significantly inhibited the gastric lesions induced by pylorus ligation, aspirin and alcohol. The gastric volume and total acidity were found to be significantly reduced while the gastric pH and mucus contents were found to be increased as compared to control group. The present findings suggest that the antiulcer properties of Abutilon indicum may be due to its effect on both offensive and defensive factors. These results support the ethno medical uses of Abutilon indicum in the treatment of ulcer.
Authors and Affiliations
Satish Sharma , Seshasai Sharma , Vipin Saini , Sharmistha Mohapatra
Keywords
Related Articles
- EP ID EP93266
- DOI 10.7897/2230-8407.04350
- Views 100
- Downloads 0
IN VITRO ANTIMICROBIAL ACTIVITY OF LEAVES AND BARK EXTRACTS OF FICUS RELIGIOSA (Linn.)
In the present study we investigated antimicrobial activity of diethyl ether and methanol extractions of bark and leaves of Ficus religiosa plant against three bacteria (E.coli, Staphylococcus aureus & Pseudomonas a...
FORMULATION AND IN VITRO EVALUATION OF LOVASTATIN BUCCAL TABLETS
The present investigation is concerned with formulation and in-vitro evaluation of mucoadhesive buccal tablets containing anticholesteremic agent. Lovastatin to by-pass the first pass effect and to improve its bio availa...
IN VITRO PLANT REGENERATION OF CRITICALLY ENDANGERED MEDICINAL PLANT ARTEMISIA AMYGDALINA D.
An efficient in vitro propagation protocol for Artemisia amygdalina D. developed here resulted in the induction of significantly more number of shoots (36 shoots per nodal explant) on a medium containing 10 µM benzyl ami...
IS LIFE-SPAN UNDER OUR CONTROL??
With each passing day, we age. Our body gets flooded with unwanted and deleterious elements, our cells lose their ability to divide, our nervous, endocrine and immune systems weaken with advancing age. Sagging skin, wrin...
EVALUATION OF ANTIOXIDANT POTENTIAL AND FOURIER TRANSFORM INFRARED SPECTROSCOPY ANALYSIS OF ANANUS COMOSUS (L.) MERRILL PEEL
Ananas comosus (L.) Merrill is belonging to the family Bromeliaceae which act as an anti-inflammatory, antitumor effect. The present study is aimed to appraise the antioxidant potential and Fourier transform infrared spe...