Evaluation of Antianxiety Activity of Angiotensin Receptor Blockers in Albino Mice
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 4
Abstract
Anxiety is one of the most common conditions present globally adding to economic burden along with health concern. It is most common existing condition along with other psychiatric illness as well as co morbid conditions like hypertension. Recently the role of angiotensin is gaining importance in the field of research as it modulates various brain physiologies. Hence the present study was planned to evaluate the antianxiety activity of Losartan 5mg/kg, Losartan10mg/kg, Olmesartan5mg/kg, Olmesartan10mg/kg, Telmisartan5mg/kg and Telmisartan10mg/kg in comparison with control and Diazepam0.5mg/kg. Anti-anxiety activity was evaluated using Elevated plus maze and Social interaction test in mice. Administration of Losartan10mg/kg (p<0.01), Olmesartan10mg/kg (p<0.01) and Telmisartan at both the doses (p<0.001) increased the time spent in open arms when compared to control in Elevated plus maze test and in ocial interaction, Losartan, Olmesartan and Telmisartan, at both 5mg/kg and 10mg/kg significantly increased the time spent in social interaction (p<0.00). Finally, it can conclude that the Angiotensin receptor blockers like Losartan, Olmesartan and Telmisartan have got significant antianxiety property in both lower and higher doses. Keywords: anxiety, angiotensin system, elevated plus maze, social interaction.
Authors and Affiliations
Dr. Swetha E. S, Dr. Sathisha Aithal, 3Dr. Ayesha Rubina
Keywords
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