Evaluation of Anticancer Activity of Steganotaenia Araliacea (Carrot Tree) Bark Extract in Cancer Induced Mammary Glands of Female Sprague Dawley Rats
Journal Title: BEST : International Journal of Humanities , Arts, Medicine and Sciences ( BEST : IJHAMS ) - Year 2019, Vol 7, Issue 1
Abstract
Ethnopharmacological relevance: Steganotaeniaaraliacea is a common small, aromatic, deciduous tree which is widely distributed in the rocky parts of Zimbabwe. It is used by the local population for different medicinal purposes which include; treatment of stomach aches, snake bites, the common cold, and cancer. A significant number, 40%, of registered traditional practitioners in Zimbabwe use the plant to treat cancerAim: The aim of the study was to test for the anti-tumor activity of Steganotaeniaaraliacea in 7,12-Dimethylbenz (a) anthracene (DMBA)-induced breast cancer in Sprague Dawley rats. Methodology: The anticancer activity of methanolic bark extract of S. araliacea was evaluated in-female Sprague Dawley rats with DMBA-induced breast cancer. Cancer was induced by subcutaneous injection of 20mg DMBA in virgin female Sprague Dawley rats. The plant crude extract was administered by gastric gavage on a daily basis for a period of 20 days. The doses administered were 0.22g/ml, in one test group, and 0.45g/ml, in the second test group. The study animals used had an average weight of 281g. Tumor size was determined before and after administration of the crude plant extract and compared against the antitumor effect of a standard drug, cyclophosphamide. After the study, the animals were sacrificed. Results:S.araliacea crude extract showed a significant decrease in DMBA induced mammary tumor size in the rats. Phytochemical screening of the crude extract revealed the presence of flavonoids, tannins, saponins, and alkaloids. Conclusion: The results showed that the methanolic extract of S.araliacea bark has the effect of reducing tumor size, however, is less efficacious compared to the standard drug, cyclophosphamide.
Authors and Affiliations
Patrick R Matowa, Felistus Chando, Charles F. B Nhachi & Mazuru Gundidza
Keywords
Related Articles
- EP ID EP618831
- DOI -
- Views 86
- Downloads 0
Social Realism: The Stark Reality Style, Clinched in Gopinath Mohanty’s Celebrated Novel Paraja
One of the dominating styles of post World War II era writing is ‘Social Realism’ invented during the ‘Great Depression’ in the American continent and entire Europe in contrast to Romantic Idealism. The artists and write...
Make in India: New Initiative for Growth and Development
In this paper generally all concepts about make in India complain has been discussed for making new initiative sound growth and development in the India economy. Make in India campaign has been launched by prime minister...
Optimization of RSM Calibration Models for Multiple Processes in the Sugar Industry
The measurements of Response surface methodology, combined with data analysis techniques, are widely used for quality control in food production processes. This paper presents a methodology to optimize the calibration mo...
Optimization of Blanching Process for Carrots by Response Surface Method
Aim is to study the effects of selected blanching treatments, on the quality of carrots over a temperature range of 80–100°C. The blanching treatments selected were steam, water, 0.05 N acetic acid solution and 0.2% calc...
Improved Extraction of Kokum Fruit Pulp by Optimizing Process Parameters using Response Surface Methodology (RSM) Tool
To obtain a suitable smooth kokum pulp depending on water temperature and soaking time, response surface methodology (RSM) optimal is used. Garcinia indica has many benefits and it’s grown all over India. In the present...