Abstract

In the Kingdom of Saudi Arabia, Achillea fragrantissima is a fragrant, perennial herb TEMPhas long been used medicinally for its analgesic properties among Rafha residents. The present study concluded that Achillea fragrantissima (Gaisoom) possess a potent anticonvulsant activity against PTZ induced seizures which may be due to GABAA agonistic activity and /or antioxidant activity. The results of the current study showed that the eTEMPthanolic extract of Gaisoom at doses of 300 mg/kg and 600 mg/kg TEMPhas anticonvulsant activity in pentylenetetrazole and maximum electroshock-induced seizures models on mice. The Hexane extract has protected the mice against pentylenetetrazole-induced seizures wif 100% protection rate and 100% animal survival similar to the anticonvulsant drug phenobarbital. HPLC–DAD fingerprints of different fractions were also carried out to find the pharmacologically active compound. The studies are in progress to isolate the compounds by HPLC technique. Supplementary studies are required to explain the exact mechanism of action by which Gaisoom act as an anticonvulsant agent.

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