Evaluation of antidiabetic activity of ethanolic extract of roots of pterocarpus marsupium in streptozotocin induced diabetic rats
Journal Title: Journal of Pharmaceutical and Biological Sciences - Year 2017, Vol 5, Issue 4
Abstract
The present study evaluates the effect of ethanolic bark extract of P.marsupium in streptozotocin induced diabetic rats. Diabetes was induced in rats by administering streptozotocin (50mg/ kg) intraperitonially (ip). Animals were divided into five groups (n=6) receiving different treatments: Group I: vehicle (normal Control), Group II: (diabetic control), Group III: standard antidiabetic drug glibenclamide (1 mg/ kg bw, orally), Groups IV and V: ethanolic root extract treated (200 mg and 400 mg/ kg bw, orally respectively). Blood samples were collected and analyzed for blood glucose, SGPT and SGOT after 28 days of the treatment. The ethanolic root extract of P.marsupium at the dose level of 200 and 400 mg/ kg bw, produced significant reduction in blood glucose and serum enzymes (SGPT and SGOT) level and body weight improves by the extracts at dose of 200mg/kg and 400mg/kg during treatment period. The present investigation thereby reveals the anti-hyperglycemic potential of ethanolic root extract of P.marsupium.
Authors and Affiliations
Abhishek N. , Karunakar Hegde, Chaithra Amin B, Ajay Kumar
Keywords
Related Articles
- EP ID EP321953
- DOI -
- Views 153
- Downloads 0
Telephone and wireless performance evaluation of pre-hospital emergency Kohgiluyeh and Boyer Ahmad in year 2016
Background and Purpose: Emergency first-line treatment of emergency. The timely arrival of an ambulance could be more injuries from an injury time for a patient is critical and can minimize the time responded to the need...
Modulations in haematological aspects of wistar rats exposed to sublethal doses of fipronil under subchronic duration
Fipronil (FPN) a phenylpyrazole insecticide is one of the preferred agricultural chemical known for controlling insect pests. Assessment of its safe and toxic levels has become a matter of serious concern as it is occupa...
The effect of an educational intervention in improving hypertension?related adherence to medication and health?related quality of life
The objective of this study is to evaluate the effect of educational intervention in improving hypertensionrelated adherence to medication and healthrelated quality of life This study includes the effects of pharmacist i...
Protective Effect of α-Momorcharin on Oxidative Damage and Antioxidant Status in Diethylnitrosamine Induced Hepatocellular Carcinoma in Animal Model
The present investigation is part of continuing programme related to the biochemical screening of local plants used in Ancient Indian Medicine, Ayurveda, Siddha and Yunani. Our study aims at elucidating the antioxidant e...
Toxicological evaluation of the aqueous extract of Pseudocedrela kotschyi (Meliaceae) stem bark in albino rats
Pseudocedrela kotschyi is a monoiceous plant used traditionally to treat many diseases. The present work has been designed to evaluate the toxicological profile of aqueous extract of Pseudocedrela kotschyi stem bark in e...