Evaluation of Antiepileptic Property of Citrus Sinensis (Leaf Extract) By Pentylenetetrazol (PTZ) Induced Convulsions in Mice
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 7
Abstract
Abstract:Citrus sinensis common name sweet orange belong to Rutaceae family was widely cultivated all over the world.Citrus plant contains large amounts of flavonoids which are found to be beneficial to human health. Leaf extracts of Citrus sinensis have been used to treat neurological diseases. We in the present tried to evaluate the anti-epileptic property of hydro-ethalonic leaf extracts of Citrus sinensis. The method utilized was the ability of Citrus sinensis to inhibit Pentylenetetrazole (PTZ) induced convulsions in mice. The mice were divided into 4 groups having 6 mice each with Group I receiving distilled water, Group II receving Sodium valproate 150mg/kg i.p. Group III receiving Citrus sinensis hydro-ethalonic extracts of 50mg/Kg p.o. and Group IV Citrus sinensis 100mg/kg p.o.The mice were closely observed for 30 minutes and the following parameters were recorded, Onset of convulsion, Duration of convulsion and Time of recovery Percentage of inhibition of seizures compared with standard drug Sodium valproate. In group I the mean duration to onset of convulsion was 339.83 sec, the duration of convulsion was 24.33sec and time to recovery was 561.5 sec. In group II none of the mice developed convulsions. In group III the mean duration to onset of convulsion was 2568.75 sec the duration of convulsion was 19.0 sec and time to recovery was 395.0 sec. similarly for group IV the mean duration to onset of convulsion was 2848.5 Sec, the duration of convulsion was for 10.75 sec and time to recovery was 313.75 sec. Hydro-ethalonic extracts of Citrus sinensis possess anti-epileptic properties. However its antiepileptic properties are lesser when compared to sodium valproate. It may be used as an adjuvant therapy along with standard anticonvulsant drugs in seizure prevention. Keywords:Citrus sinensis, Hydro-ethalonic extracts, Anti-epileptic.
Authors and Affiliations
Jaya Babu Nagula, Nadithe Laxman Reddy
Keywords
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