Evaluation of Antimicrobial Potential of Saccharomonospora oceani VJDS-3: A Study on optimization of Fermentation Parameters
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
A study has been undertaken to isolate potent rare actinobacteria from Mangrove ecosystem of Nizampatnam, Guntur district of Andhra Pradesh, India. Among the 20 different actinobacterial strains isolated, one potent strain with broad spectrum antagonistic activity was identified as Saccharomonospora oceani VJDS-3. Attempts were made to optimize the cultural parameters for enhanced antimicrobial metabolite production. Production of bioactive metabolites by the strain was high in yeast extract malt extract dextrose broth as compared to other tested media. The strain utilized maltose and tryptone as good carbon and nitrogen sources for the elaboration of bioactive metabolites. The optimum temperature and pH for bioactive metabolite production of the strain were recorded as 30oC and 7.0 respectively. The secondary metabolites produced by the strain grown under optimal conditions exhibited high antagonistic activity against a variety of Gram positive, Gram negative bacteria and fungi. This is the first report on the optimization studies of bioactive metabolite production by Saccharomonospora oceani.
Authors and Affiliations
Mani Deepa Indupalli, Vijayalakshmi Muvva*, Rajesh Kumar Munaganti
Keywords
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