EVALUATION OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF TWO ISOLATES FROM ASPILIA AFRICANA [PERS] C.D. ADAMS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
Aspilia africana [PERS] C.D. Adams belong to the family of Asteraceae. It is a medicinal plant used by traditional herbal practitioners in Nigeria and some parts of West Africa for the treatment of various infections of bacterial origin (gonorrhea and stomach trouble). Powdered plant material was subjected to phytochemical screening using standard experimental procedures. Bioassay directed fractionation of the ethyl acetate soluble leaves extract has led to the isolation of two active compounds identified as: trans Ethyl 3 – (3, 4 – dihydroxyphenyl) acrylate 1 and 3-(4-hydroxyphenyl)-2-oxo-2H-chromene-6-carbaldehyde 2. The molecular structure elucidation of both compounds was carried out using spectroscopic studies (1HNMR, 13CNMR, and MS). These compounds were reported from this species for the first time. A DPPH spectrophotometric assay was used to evaluate the antioxidant potential of the compounds while their antimicrobial activities were carried out using agar diffusion and bioautography methods. Compound 1 had very strong antioxidant activity (EC50 14.49 ± 0.84 μM) in comparison with L-ascorbic acid (EC50 13.18 ± 0.63 μM) which was used as standard.
Authors and Affiliations
Francis Faleye , Oguntuga Ogundaini
Keywords
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